Tremethick DJ (1998) Chromatin Assembly in Xenopus Extracts. Methods in Enzymology (manuscript accepted for publication)
Tremethick DJ (1998) Preparation of chromatin assembly extracts from Xenopus oocytes. Methods in Molecular Biology "Chromatin". (Humana Press). In press
Cytokine Gene Transcription Laboratory
Shannon MF, Himes SR and Attema JA(1998) Role for the architectural transcription factors HMGI(Y) in cytokine gene transcription in T cells. Immunol and Cell Biol. 76:461-466
Kochetkova M and Shannon MF (1998) DNA Triplex formation on the GM-CSF gene proximal promoter. Nucleosides and Nucleotides 17:1801-1807
Catron KM, Brickwood JR, Shang C, Li Y, Shannon MF and Parks TP(1998) Cooperative binding and synergistic activation by RelA and C/EBPb on the ICAM-1 promoter. Cell Growth and Differentation. 9:949-959
Kochetkova M and Shannon MF (1998) DNA triplex as a tool to regulate cytokine gene expression. Methods in Molecular Biology. In press
Himes SR and Shannon MF (1998) Assays for transcriptional activity based on the luciferase reporter gene. Methods in Molecular Biology. In press
Kochetkova M and Shannon MF (1998) Triplex forming oligonucleotides and their use in analysis of gene transcription. Triple Helix Forming Oligonucleotides: Developments in Antisense Research. In press
Charlton B, Fathamn CG and Slattery RM: (1998) Th1 unresponsiveness can be infectious for unrelated antigens. Immunology and Cell Biology 76:173-178
Hogan SP, Foster PS, Charlton B and Slattery RM: (1998) Prevention of Th2 mediated murine allergic airways disease by soluble antigen administration in the neonate. Proc. National Academy of. Science USA 95: 2441-2445
Medical Molecular Biology Group
Kamei M, Webb GC, Young IG, and Campbell HD (1998) SOLH, a human homologues of the Drosophila melanogaster small optic lobes gene is a member of the calpain and zinc-finger gene families and maps to human chromosome 16p13.3 CATM (Cataract with Microphthalmia). Genomics 51: 97-206
Hogan SP, Matthaei KI, Young JM, Koskinen A, Young IG, and Foster PS (1998) A Novel T-cell Regulated Mechanism Modulating Allergen-Induced Airways Hyperreactivity in BALB/c Mice Independently Of Interleukin -4 and -5. J Immunology 161(3): 1501-1509
Bao S, Beagley KW, Caristo V, Matthaei KI, Young IG, and Husband AJ (1998) Intestinal IgA Plasma cells of the B-1 lineage are IL-5 dependent. Immunology 94:181-188
Freeman FM and Young IG (1998) Chloramphenicol-induced amnesia for passive avoidance training in the day-old chick. Neurobiology of Learning and Memory. 71: 80-93
Hogan SP, Mould AW, Young JM, Rothenberg M, Ramsay AJ, Matthaei KI, Young IG and Foster PS (1998) “Cellular and Molecular Regulation of Eosinophil Trafficking to the Lung”, Immunology and Cell Biology 76: 454-460
Tan CL, Fisher JA, van Leeuwen BH, Matthaei KI and Young IG (1999) Regulation of interleukin-5 expression in T lymphocytes: repression by dexamethasone. In Interleukin-5: From Molecule to Drug Target for Asthma. C.J. Sanderson, Ed., Marcel Dekker, New York. 289-295
Foster PS, Hogan SP, Matthaei KI and Young IG (1999) The role of interleukin-5 in allergic airways disease. In Interleukin-5: From Molecule to Drug Target for Asthma. C.J. Sanderson, Ed., Marcel Dekker, New York. 127-135
Wang J, Pansky A, Venuti JM, Yaffe D and Nudel U (1998) “A Sea Urchin Gene Encoding Dystrophin-Related Proteins”, Human Molecular Genetics 7:581-588
Simeonovic CJ, Townsend MJ, Morris CF, Hapel AJ, Fung M-C, Mann DA, Young IG and Wilson DJ Immune Mechanisms Associated with the Rejection of Fetal Murine Proislet Allografts and Pig Proislet Xenografts: Comparison of Intragraft Cytokine mRNA Profiles. In press
Simeonovic CJ, Townsend MJ, Karupiah G, Wilson DJ, Zarb JC, Mann DA and Young IG Analysis of the Th1/Th2 Paradigm in Transplantation: Interferon-Deficiency Converts Th1-Type Proislet Allograft Rejection to the Th2-Type Xenograft-Like Response. In press
Leukocyte Signalling and Regulation Laboratory
Hogan SP, Koskinen A, Matthaei KI, Young IG and Foster PS: (1998) Interleukin-5 producing CD4+ T cells play a pivotal role in aeroallergen-induced eosinophilia, bronchial hyperreactivity and lung damage in mice. Am. J Resp. and Crit. Care Med. 157, 210-218
Hogan SP, Foster PS, Charlton B and Slattery RM (1998) Prevention of TH2 mediated allergic airways disease by soluble antigen administration in the neonate. Proc. Natl. Acad. USA 95: 2441-2445
Hogan SP, Foster PS, Tan X and Ramsay AJ (1998) Mucosal interleukin-12 gene delivery inhibits allergic airways disease and restores local anti-viral immunity. European J Immunol. 28: 413-423
Hogan SP, Matthaei KI, Young JM, Koskinen A, Young IG and Foster PS (1998) A novel T-cell regulated mechanism modulating allergen induced airways hyperreactivity in BALB/c mice independently of interleukin-4 and -5. J Immunology. 161, 1501-1509
Temelkorski J, Hogan SP, Foster PS and Kummar JRK (1998) An improved murine model of asthma. Selective airway inflammation, epithetial cell damage and increased methacholine responsiveness following chronic exposure to low concentrations of aerosolised allergen. Thorax. 53. 10, 849-856
Foster PS and Hogan SP (1998) Cytokine and adhesion molecule antagonists. In anti-inflammatory drugs and asthma. Editors AP Sampson and MR Church. In press
Foster PS, Hogan SP, Matthaei KI and Young IG (1998) The role of interleukin-5 in allergic airways disease. In molecule to drug target for asthma. Editor C Sanderson. In press
Simson L and Foster PS (1998) Chemokine and cytokine co-operactivity. In cytokines and chemokines. Editor, M Rothenberg. In press
Foster PS (1998) STAT6: An intracellular target for the inhibition of allergic desease. J Clin. Exp. Allergy. In press
Hogan SP , Mould AW, Young J, Rothenberg ME, Ramsay AJ, Matthaei KI, Young IG and Foster PS (1998) Cellular and molecular regulation of eosinophil trafficking to the lung. Immun. and Cell. Biology. In press
Gene Targeting Laboratory
Hogan SP, Koskinen A, Matthaei KI, Young IG and Foster PS (1998) "IL-5 producing CD4+ T-cells play a pivotal role in the induction of eosinophilia and allergic airways disease in mice" American Journal of Respiratory and Critical Care Medicine, 157(1), 210-218
Kelleher KL, Matthaei KI, Leck KJ & Hendry IA (1998) "Developmental expression of messenger RNA levels of the a subunit of the GTP-binding protein, Gz, in the mouse nervous system" Developmental Brain Research,107, 247-253
Matthaei KI, Berry JR, France MP, Yeo C, Garcia-Aragon J & Russel PJ (1998) "Use of Polymerase Chain Reaction to Diagnose a Natural Outbreak of Mouse Hepatitis Virus Infection in Nude Mice". Laboratory Animal Science, 48, 137-144
Bao S, Beagley KW, Murray AM, Caristo V, Matthaei KI, Young IG & Husband AJ "Intestinal IgA Plasma cells of the B-1 lineage are IL-5 dependent". Immunology, 94, 181-188
Wang J, Palmer K, Lötvall J, Milan S, Lei X-F, Matthaei KI, Gauldie J, Inman MD, Jordana M & Xing Z (1998) "Circulating, but not local lung, IL-5 is required for the development of antigen-induced airways eosinophilia" Journal of Clinical Investigations 102, 1132-1141
Hogan SP, Matthaei KI, Young JM, Koskinen A, Young IG & Foster PS (1998) "A novel T-cell regulated mechanism modulating allergen-induced airways hyperreactivity in BALB/c mice independently of IL-4 and IL-5" The Journal of Immunology 161, 1501-1509
Ovington KS, McKie KE, Matthaei KI, Young IG & Behm CA (1998) "Regulation of primary Strongyloides ratti infections in mice: a role for interleukin-5". Immunology 95, 488-493
McHenry JZ, Leon A, Matthaei KI & Cohen DR (1998) "Over expression of fra-2 in transgenic mice perturbs normal eye development" Oncogene 17, 1131-1140
Hogan SP, Mould AW, Young JM, Rothenberg ME, Ramsay AJ, Matthaei KI, Young IG & Foster PS (1998) "Cellular and Molecular Regulation of Eosinophil Trafficking to the Lung" Immunology and Cell Biology 76, 454-460
Biological NMR Laboratory
Flanagan JU, Chelvanayagam G, Casarotto MG, Parker MW & Board PG (1998) A mutagenic analysis of the role of Arg-107 and Trp-115 in the human Theta class glutathione GSTT2-2, Clinical Chemistry and Enzymology. In press
Computational Molecular Biology & Drug Design Group
Bliznyuk AA and Gready JE: (1998) Identification and energetic ranking of possible docking sites for pterin on dihydrofolate reductase. Journal of Computer-Aided Molecular Design. 12:325-333
Cummins PL and Gready JE: (1998) A molecular dynamics and free energy perturbation (MD/FEP) study of the hydride-ion transfer step in dihydrofolate reductase using a combined quantum and molecular mechanical (QM/MM) model. Journal of Computational Chemistry. 19:977-988
Cummins PL and Gready JE: (1998) Investigating enzyme reaction mechanisms with QM/MM+MD calculations. In: Hybrid Quantum Mechanical and Molecular Mechanical Methods (eds. J Gao and MA Thompson) ACS Symposium series No 712, Ch 16. American Chemical Society, Washington. In press
Gready JE, Ranganathan S and Cummins PL: (1998)Reaction mechanisms in enzyme active sites using a "divide and conquer" approach: hybrid quantum and molecular mechanics (QM/MM). In: Advances in Computational Life Sciences, Vol. 2: Humans to Proteins (ed. Michaelowicz, MT) CSIRO Publishing, Melbourne, pp. 201-212
Harvey PJ, Gready JE, Hickey HM, Le Couteur DG and McLean AJ: (1998) 31P and 1H NMR spectroscopic studies of liver extracts of carbon tetrachloride treated rats. NMR in Biomedicine. In press
King WA, Gready JE and Andrews TJ: (1998) Quantum chemical analysis of the enolisation of ribulose-bisphosphate: the first hurdle in the fixation of CO2 by Rubisco. Biochemistry. 44: 15414-15422
Rendell A, Bliznyuk A, Huber T, Limaye A, Gready J, Greatbanks S and Schmidt R: (1998) Hybrid quantum mechanical/molecular mechanical (QM/MM) studies of enzyme reaction mechanisms: building the computational engine. In: HPC - Technology Driver for Academia, Business and Industry, Vol. 1 (eds. KY Lam, BC Khoo and K Kumar), Institute of High Performance Computing, Singapore, pp. 153-160
Membrane Biochemistry Group
Tierney ML, Birnir B, Cromer B, Howitt SM, Gage PW and Cox GB (1998) Two Threonine Residues in the M2 Segment of the alpha-1 beta-1 GABAA Receptor are Critical for Ion Channel Function. Receptors and Channels 5: 113-124
Ewart GD and Howells AJ (1998) ABC transporters involved in transport of eye-pigment precursors in rosophila Melanogaster." Methods in Enzymology 292 [16]
Hatch LP, Cox GB and Howard SM (1998) Glutamate residues at positions 219 and 252 in the alpha-subunit of the Escherichia coli: ATP synthase are not functionally equivalent. Biochimica et Biophysica Acta 1363:217-223
Membrane Physiology and Biophysics Group
Chung S-H, Gage PW. (1998) Signal processing techniques for channel current analysis based on hidden markov models. In: Michael Conn P (ed). Methods in Enzymology. Academic Press.New York, USA: pp. 420-437. (1998)
Gage PWSpecial Feature: Signal transmission in ligand-gated receptors. Immunology and Cell Biology 76:436-440
Hammarström AKM, Gage PW, (1998) Inhibition of oxidative metabolism increases persistent sodium current in rat CA1 hippocampal neurons. J Physiol 510.3:735-741
Piller SC, Jans P, Gage PW, Jans DA (1998) Extracellular HIV-1 VPR causes a large inward current and cell death in cultured hippocampal neurons: implications for aids pathology. PNAS 95:4595-4600
Tierney ML, Birnir B, Cromer B, Howitt SM, Gage PW, Cox GB (1998) Two threonine residues in the M2 segment of the alpha-1 beta-1 GABAA receptor are critical for ion channel function. Receptors and Channels 5:113-124
Hammarström AKM, Parkington HC, Coleman HA Endothelium-dependent hyperpolarization in resting and depolarized mammary and coronary arteries of guinea-pigs. Br J Pharmacol. In press
Muscle Research Group
Ahern GP, Junankar PR, Dulhunty AF (1998) Subconductance states in single-channel activity of skeletal muscle ryanodine receptors after removal of FKBP12. Biophys J 72:146-162
Ahern GP, Junankar PR, Pace SM, Curtis S, Mould JA, Dulhunty AF (1999) Effects of ivermectin and midecamyoin on ryanodine receptors and the Ca2+-ATPase in sarcoplasmic reticulum of rabbit and rat skeletal muscle. J Physiol Vol 514.2:313-326
Ahern GP, Laver DR (1998) ATP inhibition and rectification of a Ca2+-activated anion channel in sarcoplasmic reticulum of skeletal muscle. Biophys J 74:2335-2351
Balog EM, Gallant EM Modulation of sarcolemmal L-current by alteration in SR Ca2+ release. Am J Physiol. In press
Dulhunty AF, Laver DR, Gallant EM, Pace SM, Curtis S Activation and inhibition of skeletal RyR channels by a part of the skeletal DHPR 11-111 loop: effects of DHPR SER689 and FKBP12. Biophys J In press]
Eager KR, Dulhunty AF Cardiac Ryanodine receptor activity is altered by oxidising reagents in eigher the luminal or cytoplasmic solution. J Memb Biol. In press
Eager KR, Dulhunty AF (1998) Activation of the cardiac ryanodine receptor by sulfhydryl oxidation is modified by Mg2+ and ATP J Memb Biol 163:9-18
Enzmann N, Balog EM, Gallant EM (1998) Porcine malignant hyperthermia: effects of sarcoplasmic reticulum Ca2+ pump inhibition. Muscle and Nerve 21:361-366
Lamb GD, Laver DR (1998) Adaptation, inactivation and inhitition in ryanodine receptors. In: Sitsapesan R, Williams AJ (ed). Ryanodine receptor structure and function
Laver DR, Lamb GD (1998) Inactivation of Ca2+ release channels (ryanodine receptors RyR1 and RyR2) with rapid steps in [Ca2+] and voltage. Biophys J 74:2352-2364
Laver DR, Owen VJ, Junankar PR, Taske NL, Dulhunty AF, Lamb GD (1998) Reduced inhibitory effect of Mg2+ on ryanodine receptor -Ca2+ release channels in malignant hyperthermia. Biophys J 73:1913-1924
Lentz LR, Valberg SJ, Mickelson JR, Gallant EM In vitro contractile responses and contrature testing of Quarter Horse with exertion rhabdomyolysis. Am J Vet Res. In press
Lentz L, Valberg SJ, Balog EM, Michelson JR, Gallant EM Abnormal regulation of muscle contraction in equine exertion rhabdomyolysis. Am J Vet Res. In press
Mould JA, Dulhunty AF Effects of external cadmium ions on excitation-contraction coupling in rat soleus fibres. Pflugers Arch 437: 197-203
Valberg SJ, Michelson JM, Gallant EM, Macleay JM, Lentz L, DeLaCorte F Exertional rhabdomyolysis in Quarter Horses and Thoroughbreds: one syndrome, two etiologies. Am J Vet Res. In press
Protein Chemistry LaboratoryMesser M, Weiss AS, Shaw DC and Westerman M (1998) Evolution of the Monotremes: phylogenetic relationship to Marsupials and Eutherians, and estimation of divergence dates based on alpha-lactalbumin amino acid sequences. Journal of Mammalian Evolution. 5: 95-105
Simpson KJ, Bird P, Shaw D and Nicholas K (1998) Molecular characterisation and hormone-dependent expression of the porcine whey acidic protein gene. Journal of Molecular Endocrinology. 20: 27-35
Simpson KJ, Shaw DC and Nicholas KR (1998) Developmentally-regulated expression of a putative protease inhibitor gene in the mammary gland during lactation in the tammar wallaby, Macropus eugenii. Comparative Biochemistry and Physiology Part B 120: 535-541
Truscott RJW, Chen YC and Shaw DC (1998) Evidence for the participation of alphaB-crystallin in human age-related nuclear cataract. International Journal of Biological Macromolecules. 22: 321-330
Nuclear Signalling Laboratory
Piller SC, Jans P, Gage PW and Jans DA. (1998) "Extracellular HIV-1 Vpr causes a large inward current and cell death in cultured hippocampal neurons: implications for AIDS pathology" Proc. Natl. Acad. Sci. USA 95, 4595-4600
Jans DA and Hassan G (1998) "Nuclear targeting by growth factors, cytokines and their receptors: a role in signaling ?" Bioessays 20, 400-411
Efthymiadis A, Briggs LJ and Jans DA (1998) "The HIV-1 Tat nuclear localization sequence confers novel nuclear import properties" J Biol. Chem. 273, 1623-1628
Trapani JA, Jans P, Smyth MJ, Froelich CJ, Williams EA, Sutton VR and Jans DA (1998) "Perforin-dependent nuclear entry of granzyme B precedes apoptosis and is not a consequence of nuclear envelope dysfunction" Cell Death and Differentiation 5, 488-496
Briggs LJ, Stein D, Goltz J, Corrigan VC, Efthymiadis A, Hübner S and Jans DA (1998) "The PK-A site (Ser312) enhances Dorsal nuclear import through facilitating nuclear localization sequence/importin interaction" J Biol. Chem. 273, 22745-22752
Efthymiadis A, Dottorini T and Jans DA (1998) "A novel system to quantitate nuclear-cytoplasmic flux: kinetics of signal-dependent nuclear protein export" Arch. Biochem. Biophys. 355, 254-261
Chan CK, Hübner S, Hu W and Jans DA (1998) "Mutual exclusivity of DNA binding and nuclear localization signal recognition by the yeast transcription factor GAL4: implications for non-viral DNA delivery" Gene Therapy, 5, 1204-1212
Jans DA, Briggs LJ, Jans P, Sutton VR, Parasivam G, Williams EA, Kumar S, Froelich CJ and Trapani JA (1998) "Nuclear targeting of the serine protease granzyme A (fragmentin-1)" J Cell Sci., 111, 2645-2654
Jans DA, Chan CK and Huebner S (1998) "Signals mediating nuclear targeting and their regulation; application in drug delivery" Med. Res. Reviews 18, 189-223
Jans DA "Protein targeting to the nuclear compartment" Australian Biochemist 29, 5-10. (1998)
Trapani JA, Jans DA, Jans P, Smyth MJ, Browne KA and Sutton VR (1998) "Nuclear targeting of granzyme B and the nuclear consequences of apoptosis induced by granzyme B and perforin are caspase-dependent, but cell death is caspase-independent" J Biol. Chem., 273, 27934-27938
Xiao C-Y and Jans DA (1998) "An engineered site for protein kinase C flanking the SV40 large T-antigen NLS confers phorbol ester-inducible nuclear import" FEBS Lett., 436, 313-317
Xiao C-Y, Jans P and Jans DA (1998) "Negative charge at the protein kinase CK2 site enhances recognition of the SV40 large tumor-antigen nuclear localization signal by importin; effect of proline near the CK2 site" FEBS Lett:440, 297-301
Blink EJ, Trapani JA and Jans DA (1999) "Perforin-dependent nuclear targeting of granzymes: central role in the nuclear events of granule-exocytosis-mediated apoptosis?" Immunol. Cell Biol. In press
Trapani JA and Jans DA (1998) Lymphocyte-mediated cytolysis: dual apoptotic pathways with overlapping cytoplasmic and nuclear signalling pathways, in Apoptosis: biology, mechanisms and role in disease (Kumar S, ed), Springer-Verlag, Heidelberg, pp 75-102
Trapani JA, Jans DA and Sutton VR (1998) Lymphocyte granule-mediated cell death. Seminars in Immunopathology 19: 323-343
Visiting Fellows
Armarego WF and Taguchi H (1998) Glyceryl-Ether Monooxygenase [EC1.14.16.5]. A+ Microsomal Enzyme of Ether Lipid Metabolism. J Wiley & Sons, Inc
Armarego WF (1998) A twenty year association with pteridines - Chemistry, Biochemistry and Molecular Biology. Pteridines 9:55-68
Barlin GB (1998) Imidazo[1,2-b]pyridazines: Syntheses and Interaction with Central and Peripheral-Type (Mitochondrial) Benzodiazepine Receptors. J Heterocyclic Chem. 35, 1205-1217
Morrison JF (1998) 41 entries on Enzyme Kinetics in The Encyclopedia of Molecular Biology (ed. Creighton TE) John Wiley, New York. In press
Morrison JF (1998) Mo Cleland and the Resurgence of Enzymology in Enzymatic Mechanisms, Perry Frey & Dexter Northrop (eds). IOS Press Van Diemenstraat 94 Amsterdam 1013 CN, Neterhlands. In press
Ada, GL: (1998) An immunologist's view of HIV infection. In: Textbook on AIDS Medicine (ed. Broder, S, Merigan, RC and Bolognesi, D) Lippincott, Williams and Wilkins, Baltimore, pp. 87-98
Ada, GL: (1998) Vaccination strategies to control infections: Overview. Molecular Biotechnology 8, 123-134
Ada, GL: Immune response. General features. In: Encyclopedia of Virology (ed. Webster, RG and Granoff, A) Academic Press. In press
Ada, GL: Vaccines and immune response. In: Encyclopedia of Virology (ed. Webster, RG and Granoff, A) Academic Press. In press
Ada, GL: The coming of age of tumour immunotherapy. Immunology and Cell Biology. In press
Ada, GL: Challenges of chronic persisting infections of global importance for vaccine developers. In: Biosciences 2000 (ed. Pasternak, C). In press
Blanden, RV, Rothenfluh, HS, Zylstra, P, Weiller, G and Steele, EJ: (1998) The signature of somatic hypermutation appears to be written into the germline IgV segment repertoire. Immunological Reviews 162, 117-132
Blanden, RV and Steele, EJ: (1998) A unifying hypothesis for the molecular mechanism of somatic mutation and gene conversion in rearranged immunoglobulin variable genes. Immunology and Cell Biology 76, 288-293
Colombage, G, Hall, R, Pavy, M and Lobigs, M: (1998) DNA-based and alphavirus-vectored immunisation with prM and E proteins elicits long-lived and protective immunity against the flavivirus, Murray Valley encephalitis virus. Virology 250, 151-163
Foletta, VC, Segal, DH and Cohen, DR: (1998) Transcriptional regulation in the immune system: all roads lead to AP-1. The Journal of Leukocyte Biology 63, 139-152
Gautam, AM, Liblau, R, Chelvanayagam, G, Steinman, L and Boston, T: (1998) A viral peptide with limited homology to a self peptide can induce clinical signs of experimental autoimmune encephalomyelitis. Journal of Immunology 161, 60-64
McHenry, JZ, Leon, A, Matthaaei, KI and Cohen, DR: (1998) Overexpression of fra-2 in transgenic mice perturbs normal eye development. Oncogene 17, 1131-1140
McKeage, MJ, Papathanasiou, P, Salem, G, Sjaarda, A, Swiegers, GF, Waring, P and Wild, SB: (1998) Antitumour activity of Gold(I), Silver(I) and Copper (I) complexes containing chiral tertiary phosphines. Metal-Based Drugs 5, 217-224
Russell, L, Waring, P and Beaver, JP: (1998) Increased cell surface exposure of fucose residues is a late event in apoptosis. Biochemical and Biophysical Research Communications 250, 449-443
Steele, EJ, Lindley, RA and Blanden, RV: (1998) Lamarck's Signature: How retrogenes are changing Darwin's natural selection paradigm, (Davies, P, ed. ), Allen and Unwin, Sydney, Australia. pp. 286
Stocks, CE and Lobigs, M: (1998) Signal peptidase cleavage at the flavivirus C-prM junction: dependence on the viral NS2B-3 protease for efficient processing requires determinants in C, the signal peptide, and prM Journal of Virology 72, 2141-2149
Weiller, G, Rothenfluh, HS, Zylstra, P, Gay, LM, Averdunk, H, Steele, EJ and Blanden, RV: (1998) Recombination signature of germline immunoglobulin variable genes. Immunology and Cell Biology 76, 179-185
Zylstra, P, Rothenfluh, HS, Weiller, GF, Blanden, RV and Steele, EJ: (1998) PCR amplification of murine immunoglobulin germline V genes: strategies for minimisation of recombination artefacts. Immunology and Cell Biology 76, 395-405
Molecular Immunology and Immunopathology Group
Mullbacher, A, Lobigs, M, Kos, FJ and Langman, R: (1998) Alloreactive cytotoxic T cells function peptide unspecific. Scandinavian Journal of Immunology. In press
Mullbacher, A, Lobigs, M, Yewdell, J, Bennink, J, Tha Hla, R and Blanden, RV: (1999) Spontaneous mutation at position 114 in H-2Kd affects cytotoxic T cell responses to influenza virus infection. European Journal of Immunology 29:1-7
Mullbacher, A, Tha Hla, R, Museteanu, C and Simon, MM: (1999) Perforin is essential for the control of ectromelia virus but not related poxviruses in mice. Journal of Virology 73, 1665-1667
Mullbacher, A and Blanden, RV: (1998) Cytotoxic T cell memory. In: Cytotoxic Cells: Basic Mechanisms and Medical Applications (ed. Sitkovsky, MV and Henkard, P) Lippincott-Raven Press..In press
San Gil, F, Turner, B, Mullbacher, A, Walker, MJ, Djordjevic, SP, Eamens, GJ and Chin, JC: (1998) Flow cytometric analysis of cellular lchanges in mice after intradermal inoculation with a liposome-iscom adjuvanted vaccine. Scandinavian Journal of Immunology 47, 243-253
Simon, MM and Mullbacher, A: (1998) Role of granzymes in target cell lysis and viral infections. In: Cytotoxic Cells: Basic Mechanisms and Medical Applications (ed. Sitkovsky, MV and Henkard, P) Lippincott-Raven Press. In press
Cell-Cell Interaction Group
Al Yaman, F, Genton, B and Clark, IA: (1998) The ratio of reactive nitrogen intermediates to tumour necrosis factor in serum predicts outcome of falciparum malaria disease. Transactions of the Royal Society of Tropical Medicine and Hygiene 92, 417-420
Alleva, LM, Clark, IA and Ovington, KS: (1998) A pro-parasitic effect for TNF in Eimeria vermiformis. International Journal for Parasitology. In press
Bradbury, MG, Qiu, MR and Parish, CR: (1997) The immunomodulatory compound 2-acetyl-4-tetrahydroxybutyl imidazole causes sequestration of lymphocytes in non-lymphoid tissues. Immunology and Cell Biology 75, 497-502
Clark, IA and Jacobson, LS: (1998) Do babesiosis and malaria share a common disease process? Annals of Tropical Medicine and Hygiene 92, 482-485
Clark, IA, Awburn, MM and Cowden, WB: (1998) Pathophysiology of Ebola haemorrhagic fever. Transactions of the Royal Society of Tropical Medicine and Hygiene 92, 469
Cowden, WB, Cullen, FA, Staykova, MA and Willenborg, DO: (1998) Nitric oxide is a potential down-regulating molecule in autoimmune disease: inhibition of nitric oxide production renders PVG rats highly susceptible to EAE Journal of Neuroimmunology 88, 1-8
Freeman, CC and Parish, CR: (1998) Human platelet heparanase: Purification, characterisation and catalytic activity. Biochemical Journal 330, 1341-1350
Hulett, MD and Hogarth, PM: (1998) The second and third domains of FcgRI (CD64) confer the unique high affinity binding of Ig G2a. Molecular Immunology 35, 989-996
Parish, CR and O'Neill, E: (1998) Dependence of the adaptive immune response on innate immunity: Some questions answered but new paradoxes emerge. Immunology and Cell Biology 75, 523-527 (1997)
Parish, CR, Hindmarsh, EJ, Bartlett, MR, Staykova, MA, Cowden, WB and Willenborg, DO: (1998) Treatment of central nervous system inflammation with inhibitors of basement membrane degradation. Immunology and Cell Biology 76, 104-113
Parish, CR: (1998) Innate immune mechanisms: non-self recognition. In: Encyclopaedia of Life Sciences,Macmillan, London. In press
Smith, JR, Hart, PH, Parish, CR, Standfield, SD, Coster, DJ and Williams, KA: (1998) Experimental melanin-induced uveitis in the Fischer 344 rats is inhibited by anti-CD4 monoclonal antibody, but not by mannose-6-phosphate. Clinical and Experimental Immunology. In press
Vassiliou, G, Jakobsen, K and Parish, CR: (1998) Detection of low affinity adhesion ligands by linking recombinant cell adhesion molecules in uniform orientation to a fluorescently labelled dextran molecule by means of hexahistidine tagging: the case of multimeric CD40. Journal of Immunological Methods 215, 9-15
Wines, BD, Hulett, MD, Jameison, GP, Trist, H, Spratt, J and Hogarth, PM: (1998) Characterisation of the IgA binding site of FcaRI and the identification of residues in the first domain essential for interaction with IgA Journal of Immunology . In press
Viral Engineering and Cytokine Group
Estcourt, MJ, Ramshaw, IA and Ramsay, AJ: (1998) Cytokine responses in virus infections: Effects on pathogenesis, recovery and persistence. Current Opinion in Microbiology 1, 411-418
Hogan, SP, Foster, PS, Tan, X and Ramsay, AJ: (1998) Mucosal interleukin-12 gene delivery inhibits allergic airways disease and restores local antiviral immunity. European Journal of Immunology 28, 413-423
Hogan, SP, Mould, AW, Young, JM, Rothenberg, ME, Ramsay, AJ, Matthaei, K, Young, IG and Fostetr, PS: (1998) Cellular and molecular regulation of eosinophil trafficking to the lung. Immunology and Cell Biology 76, 454-460
Karupiah, G, Sacks, T, Klinman, D, Fredrickson, T, Hartley, JW, Chen, J-H and Morse III, HC: (1998) Murine cytomegalovirus infection-induced polyclonal B cell activation is independent of CD4+ T cells and CD40. Virology 240, 12-26
Karupiah, G: (1998) Type 1 and type 2 cytokines in antiviral defense. Veterinary Immunology and Immunopathology 63, 105-109
Karupiah, G, Chen, J, Mahalingam, S, Nathan, C and MacMicking, J: (1998) Rapid IFN-g-dependent clearance of influenza A virus and protection from consolidating pneumonitis in nitric oxide synthase 2-deficient mice. Journal of Experimental Medicine 188, 1541-1546
Karupiah, G, Chen, J-H, Nathan, C, Mahalingam, S and MacMicking, J: (1998) Identification of nitric oxide synthase locus 2 as an innate resistance locus against ectromelia virus infection. Journal of Virology 72, 7703-7706
Kent, SJ, Zhao, A, Best, SJ, Chandler, JD, Boyle, DB and Ramshaw, IA: (1998) Enhanced T-cell immunogenicity and protective efficacy of a human immunodeficiency virus type 1 vaccine regimen consisting of consecutive priming with DNA and boosting with recombinant fowlpox virus. 72, 10180-10188
Lansdell, KA, Delaney, SJ, Lunn, DP, Thomson, SA, Sheppard, DN and Wainwright, BJ: (1998) Comparison of the gating behaviour of human and murine cystic fibrosis transmembrane conductance regulator C1- channels expressed in mammalian cells. Journal of Physiology 508, 379-392
Mahalingam, S, Farber, JM and Karupiah, G: (1999) The IFN inducible chemokines MuMig and Crg-2 exhibit antiviral activity in vivo. Journal of Virology 73, 1479-1491
Mahalingam, S, Tan, CL and Karupiah, G: (1998) Transcriptional activation of the interferon-gamma-inducible chemokine Mig in mice deficient for interferon-gamma. Journal of Biological Chemistry. In press
Ramsay, AJ, Leong, KH, Ramsahw, IA and Tan, X: (1998) Selective modulation of mucosal immune responses by cytokines encoded in vaccine vectors. In: Immunomodulation of the Gastrointestinal Mucosa (ed. Heidt, PJ, Cebra, JC, Rusch, VD, van der Waaij, D and Walker, RI) Mongraphs of the Old Herborn University. Litterae Press, Germany, pp. 112-122
Ramsay, AJ, Hogan, SP, Foster, PS and Xiong, Y: (1998) Cytokine Gene Therapy of Allergic Airways Inflammation. In: Gene Therapy in Inflammatory Diseases. (ed. Evans, CH and Robbins, P) Progress in Inflammation Research. Birkhauser Publishing, Basel. In press
Ramsay, AJ and Beagley, KW: (1998) Development of B Lymphocytes within the Mucosal Immune System. In: Development of the Gastrointestinal Tract (ed. Sanderson, IR and Walker, WA) BC Decker Inc, Hamilton, Ontario. In press
Ramsay, AJ, Xiong, Y and Hogan, SP: (1998) Vector-directed cytokine gene delivery as a therapeutic approach in allergic airways inflammation. In: Cytokines in the Regulation of Asthma (ed. Foster, PS) Thomson Science, London. In press
Robinson, BW, Mukherjee, SA, Davidson, A, Morey, S, Musk, AW, Ramshaw, I, Smith, D, Lake, R, Haenel, T, Garlepp, M, Marley, J, Leong, C, Caminschi, I and Scott, B: (1998) Cytokine gene therapy or infusion as treatment for solid human cancer. Journal of Immunotherapy 3, 211-217
Rolph, MS, Matthaei, KI, Carbone, FR, Heath, WR and Ramshaw, IA: (1998) Loss of antiviral cytotoxic T-lymphocyte activity during high-level antigen stimulation. Viral Immunology 11, 183-189
Scalzo, AA, Farrel, H and Karupiah, G: (1998) Techniques for studying NK cell function in antiviral immunity. In: Natural Killer Cell Protocols: Cellular and Molecular Methods (ed. Campbell, KS and Colonna, M) Humana Press. In press
Simeonovic, CJ, Townsend, MJ, Karupiah, G, Mann, D and Young, IG: (1998) Analysis of the Th1/Th2 paradigm in transplantation: Interferon-g-deficiency converts Th1-type allograft rejection to a Th2-xenograft-like response. Transplantation. In press
Thomson, SA, Sherritt, M, Medveczky, J, Elliott, S, Moss, DJ, Fernando, GJP, Brown, LE and Suhrbier, A: (1998) Delivery of multiple CD8 cytotoxic T cell epitopes by DNA vaccination. Journal of Immunology 160, 1717-1723
Thomson, SA, Burrows, SR, Misko, IS, Moss, DJ, Coupar, B and Khanna, R: (1998) Targeting a polyepitope protein incorporating multiple class II-restricted viral epitopes to the secretory/endocytic pathway facilitates immune recognition by CD4+ cytotoxic T lymphocytes: A novel approach to vaccine design. Journal of Virology 72, 2246-2252
White, CA, Thomson, SA, Cooper, L, van Endert, PM, Tampe, R, Coupar, BEH, Qui, L, Parsons, PG, Moss, DJ and Khanna, R: (1998) Constitutive transduction of peptide transporter and HLA genes restores antigen processing function and cytotoxic T cell-mediated immune recognition of human melanoma cells. International Journal of Cancer 75, 590-595
Willenborg, DO, Fordham, S, O'Brien, NC, Cowden, WB and Ramshaw, IA: (1998) Tumour necrosis factor-alpha (TNF alpha) and lymphotoxin-alpha (LT alpha) in the pathology of experimental autoimmune encephalomyelitis: Is either one responsible or is there another ligand mediating disease? Research in Immunology 149, 804-810
Xiong, Y, Karupiah, G, Hogan, SP, Foster, PS and Ramsay, AJ: (1999) Inhibition of allergic airways inflammation in mice lacking nitric oxide synthase 2. Journal of Immunology 162, 445-452
Experimental Haematology Group
Banyer, JL, Goldwurm, S, Cullen, L, van der Griend, B, Zournazi, A, Smit, DJ, Powell, LW and Jazwinska, ED: (1998) The spinal muscular atrophy gene region at 5q13.1 has a paralogous chromosomal region at 6p21.3. Mammalian Genome 9, 235-239
Banyer, JL and Hapel, AJ: (1998) Myb-transformed hematopoietic cells as a model for monocyte differentiation. Journal of Leukocyte Biology. In press
Goldwurm, S, van der Griend, BF, Banyer, JL, Cullen, LM, Zournazi, A, Menzies, ML, Busfield, F, Little, PF and Jazwinska, ED: (1998) Generation of a transcription map distal to HLA-F European Journal of Human Genetics 6, 475-486
Simeonovic, CJ, Townsend, MJ, Morris, CF, Hapel, AJ, Fung, M-C, Mann, DA, Young, IG and Wilson, JD: (1998) Immune mechanisms associated with the rejection of fetal murine proislet allografts and pig proislet xenografts: comparison of intragraft cytokine mRNA profiles. Transplantation. In press
Charlton B, Fathamn CG and Slattery RM Th1 unresponsiveness can be infectious for unrelated antigens. Immunology and Cell Biology 76:173 (1998)
Hogan SP, Foster PS, Charlton B and Slattery RM Prevention of Th2 mediated murine allergic airways disease by soluble antigen administration in the neonate. Proc. National Academy of. Science U.S.A 95: 2441 (1998)
Cancer Genetics Laboratory
Cavanaugh JA, Callen DF, Wilson SR, Stanford PM, Sraml ME, Gorska M, Shlegel C, Foote S, Kohonen-Corish M and Pavli P: (1998) Analysis of Australian Crohn's disease pedigrees refines the localisation for susceptibility to inflammatory bowel disease (IBD-1) on chromosome 16. Annals of Human Genetics 62: 291-298
Kohonen-Corish MRJ, Young J, Chenevix-Trench G and Doe WF: (1998) Urokinase receptor genotypes in colorectal cancer. Carcinogenesis 19: 1149-1151
Bateman JF, Freddi S, Lamande SR, Byers P, Nasioulas S, Douglas J, Otway RT, Kohonen-Corish MRJ, Edkins E and Forrest S: (1998) Reliable and sensitive detection of premature termination mutations using a protein truncation test designed to overcome problems of nonsense-mediated mRNA instability. Human Mutation (In press)
Cardiovascular disease Group
Selley ML, Bartlett MR, Czeti AL and Ardlie NG: (1998) The role of (E)-4-hydroxy-2-nonenal in platelet activation by low density lipoprotein and iron. Atherosclerosis 140(1): 105-12,
Goodnow Laboratory
Schmidt K, Hsu C, Griffin CT, Goodnow CC and Cyster JG: (1998) Spontaneous follicular exclusion of SHP1-deficient B cells is conditional on the presence of competitor wild-type B cells. Journal of Experimental Medicine 187, 929-937
Rathmell, JC and Goodnow, CC: (1998) The in vivo balance between B cell clonal expansion and elimination is regulated by CD95 both on B cells and in their microenvironment. Immunology and Cell Biology 76, 387-394
Cornall, RJ, Cyster, JG, Hibbs, ML, Dunn, AR, Otipoby, KL, Clark, EA and Goodnow, CC: (1998) Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection. Immunity 8, 497-508
Townsend, SE and Goodnow, CC: (1998) Abortive proliferation of rare T cells induced by direct or indirect antigen presentation by rare B cells in vivo. Journal of Experimental Medicine 187, 1611-1621
Rathmell, JC, Fournier, S, Weintraub, BC, Allison, JP and Goodnow, CC: (1998) Repression of B7.2 on self-reactive B cells is essential to prevent proliferation and allow Fas-mediated deletion by CD4+ T cells. Journal of Experimental Medicine 188, 651-659
Fischer, MB, Goerg, S, Shen, L, Prodeus, AP, Goodnow, CC, Kelsoe, G and Carroll, MC: (1998) Dependence of germinal center B cells on expression of CD21/CD35 for survival. Science 280, 582-585
Prodeus, AP, Goerg S, Shen, LM, Pozdnyakova, OO, Chu, L, Alicot, EM, Goodnow, CC and Carroll, MC: (1998) A critical role for complement in maintenance of self-tolerance. Immunity 9, 721-731
Ying, H, Healy, JI, Goodnow, CC and Parnes, JR: (1998) Regulation of mouse CD72 gene expression during B lymphocyte development. Journal of Immunology 161, 4760-4767
Fang, W, Weintraub, BC, Dunlap, B, Garside, P, Pape, KA, Jenkins, MK, Goodnow, CC, Mueller, DL and Behrens, TW: (1998) Self-reactive B lymphocytes overexpressing Bcl-xL escape negative selection and are tolerized by clonal anergy and receptor editing. Immunity 9, 35-45
Healy, JI and Goodnow, CC: (1998) Positive versus negative signalling by lymphocyte antigen receptors. Annual Review of Immunology. 16, 645-670
Goodnow, CC: (1998) Old genes, new lifestyles and future medicines. Australasian Science 19, ii, pp41-42
Goodnow, CC: (1998) Cancer immunotherapy: new leads on an elusive goal. Medical Journal of Australia 169, 570-571
Healy, JI, Dolmetsch, RE, Lewis, RS, Goodnow, CC: (1998) Quantitative and qualitative control of antigen receptor signalling in tolerant B lymphocytes. Novartis Found. Symposium 215, 137-144
Cornall, RJ and Goodnow, CC: (1998) B cell antigen receptor signalling in the balance of tolerance and immunity. Novartis Found. Symposium 215, 21-30
Weintraub, BC and Goodnow, CC: (1998) Immune Responses: costimulatory receptors have their say. Current Biology 8, 575-577
Developmental Physiology Group
King, KJ, Hagan, RP, Mieno, M and McCullagh, P: (1998) Cellular interactions during the development of autoimmunity in a fetal lamb model of self-antigen deprivation. Clinical Immunology and Immunopathology, 88, 56-64
McCullagh, P: (1998) Fetal sentience and fetal surgery. Recent Advances in Anaesthesia and Analgesia, 20,107-121
McCullagh, P: (1998) Immunoregulation in experimental autoimmune disease. In: Contemporary Endocrinology. In press
Press, C McL, McCullagh, P, Griebel, P og Landsverk, T: (1998) Tidlig utvikling av B-celler hos sau. Dyrehelse. Fiske- og dyrehelseprogrammet 1995-1998, Norges forskningsråd
Diabetes Research Program
Schmidli, R and Lafferty KJ: (1998) Of mice and men. Today's Life Science 10(3)20-24
Lafferty, KJ and Gazda, LS: (1998) Co-stimulation and the regulation of autoimmunity; In: Rose NR, Mackay IR, (eds) The Autoimmune Diseases, Academic Press, pp 59-74
Human Genetics Group
Andrews, TD, Jermiin, LS, Easteal, S: (1998) Accelerated evolution of the cytochrome b gene of simian primates: adaptive evolution in concert with other mitochondrial proteins? Journal of Molecular Evolution 47, 249-257
Apostolopoulos, V, Chelvanayagam, G, Xing, PW and McKenzie, IFC: (1998) Anti-MUC1 antibodies react directly with MUC1 peptides presented by class I H2 and HLA molecules. Journal of Immunology 161, 767-775
Apostolopoulos, V, Lofthouse, SA, Popovski, V, Chelvanayagam, G, Sandrin, MS and McKenzie, IFC: (1998) Peptide mimics of a tumor antigen induce functional cytotoxic T cells. Nature Biotechnology 16, 276-280
Board, PG, Blackburn, AC, Jermiin, LS and Chelvanayagam, G: (1998) Polymorphism of Phase II enzymes: Identification of new enzymes and polymorphic variants by database analysis. Toxicology Letters. In press
Chelvanayagam, G, Knecht, L, Jenny, T, Benner, SA and Gonnet, G H: (1998) A combinational distance constraint approach to predicting protein tertiary models from known secondary structure. Folding & Design 3, 149-160
Cheung, B, Holmes, RS, Easteal, S and Beacham, IR: (1998) Evolution of Class I alcohol dehydrogenase genes in catarrhine primates: gene conversion, substitution rates, and gene regulation. Molecular Biology and Evolution. In press
Cullen, LM, Gao, X, Easteal, S, Jazwinska, EC: (1998) The haemochromatosis C282Y and H63D mutations: prevalence in non-caucasian populations. American Journal of Human Genetics 62, 1403-1407
Easteal, S: (1998) DNA and the Exodus fallacy. Australian Science 1998, 33—34
Flanagan, JU, Rossjohn, J, Parker, MW, Board, PG, Chelvanayagam, G: (1998) A homology model for the human Theta-class glutathione transferase T1-1. Proteins 33(3), 444-454
Gautam, A, Liblau, R, Chelvanayagam, G, Steinman, S, Boston, T: (1998) A viral peptide with limited homology to a self peptide can induce signs of experimental autoimmune encephalomyelitis. Journal of Immunology 161, 60-64
Jakobsen, IB, Gao, X, Easteal, S and Chelvanayagam, G: (1998) Correlating sequence variation with HLA-A allelic families: Implications for T cell receptor binding specificities. Immunology and Cell Biology 76, 135-142
Jakobsen, IB, Wilson, SR and Easteal, S: (1998) Patterns of reticulate evolution for the classical Class I and II HLA loci. Immunogenetics 48, 312-323
Jacomb, PA, Jorm, AF, Croft, L, Gao, X and Easteal, S: (1998) Failure to replicate associations of HLA and CTGB33 alleles with IQ Personality and Individual Differences. In press
Jones, RA, Jermiin, LS, Easteal, S, Patel. B and Beacham, IR: (1998) Amylase and 16S rRNA genes from a hyperthermophilic archaebacterium. Journal of Applied Microbiology. In press
Jorm, AF, Henderson, AS, Jacomb, PA, Christensen, H, Korten, AE, Rodgers, B, Tan, X and Easteal, S: (1998) An association study of a functional polymorphism of the serotonin transporter gene with personality and psychiatric symptoms. Molecular Psychiatry 3, 449-451
Kangsadalampai, S, Chelvanayagam, G, Baker, RT, Yenchitsomanus, P-T, Pung-amritt, P, Mahasandana, C and Board, PG: (1998) A novel Asn344 deletion in the core domain of coagulation factor XIII A subunit: its effect on protein structure and function. Blood 92, 481-7
Nilsson, C, Jiang, M, Pettersson, K, Iitiä, A, Mäkelä, M, Easteal, S, Herrera, R, Huhtaniemi, I: (1998) Determination of a common genetic variant of luteinizing hormone using DNA hybridization and immunoassays. Clinical Endochrinology 49, 369-376
Rossjohn, J, McKinstry, WJ, Oakley, AJ, Verger, D, Flanagan, J, Chelvanayagam, G, Tan, K-L, Board, PG and Parker, MW: (1998) The crystal structure of human theta class glutathione transferase has a sulfate binding pocket within a buried site. Structure 6, 309-322
Wise, CA, Sraml, M and Easteal, S: (1998) Departure from neutrality at the mitochondrial NADH dehydrogenase subunit 2 gene in humans, but not in chimpanzees. Genetics 148, 409-421
Zhou, J, Ng, AYN, Tymms, MJ, Jermiin, LS, Seth, AK, Thomas, RS and Kola, I: (1998) A novel transcription factor, ELF15, belongs to the ELF subfamily of ETS genes and maps to human chromosome 1p36.311, a region involved in LOH in the rearrangement in human carcinoma cell lines. Oncogene. In press
Molecular Genetics Group
Blackburn, AC, Doe, WF and Buffinton, GD: (1998) Salicylate hydroxylation as an indicator of hydroxyl radical generation in dextran sulfate-induced colitis. Free Radic Biol Med 25, 305-313
Blackburn, AC, Woollatt, E, Sutherland, GR and Board, PG: (1998) Characterization and chromosome location of the gene GSTZ1 encoding the human Zeta class glutathione transferase and maleylacetoacetate isomerase. Cytogenet Cell Genet 83(1-2):109-114
Board, PG: (1998) Identification of cDNAs encoding two human alpha class glutathione transferases (GSTA3 and GSTA4) and the heterologous expression of GSTA4-4. Biochemical Journal 330, 827-831
Board, P, Harris, M, Flanagan, J, Langton, Land Coggan, M: (1998) Genetics heterogeneity of the structure and function of GSTT2 and GSTP1. Chemico-Biological Interactions 112, 83-89
Coggan, M, Whitbread, L, Whittington, A and Board, PG: (1998) The structure and organization of the human Theta class glutathione transferase and D-dopachrome tautomerase gene complex. Biochemical Journal 334, 617-623
Flanagan, JU, Rossjohn, J, Parker, MW, Board, PGand Chelvanayagam, G: (1998) A homology model for the human Theta-class glutathione transferase T1-1. Proteins 33(3), 444-454
Harris, MJ, Coggan, M, Langton, L, Wilson, SR and Board, PG: (1998) Polymorphism of the Pi class glutathione S-transferase in normal populations and cancer patients. Pharmacogenetics 8, 27-31
Kangsadalampai, S, Chelvanayagam, G, Baker, RT, Yenchitsomanus, P-T, Pung-amritt, P, Mahasandana, C and Board, PG: (1998) A novel Asn344 deletion in the core domain of coagulation factor XIII A subunit: its effect on protein structure and function. Blood 92, 481-487
Kangsadalampai, S and Board, PG: (1998) The Val34Leu polymorphism in the A subunit of coagulation factor XIII contributes to the large range in activity and demonstrates that the activation peptide plays a role in catalytic activity. Blood 92, 2766-2770
Menegon, A, Board, PG, Blackburn, AC, Mellick, GDand LeCouteur, DG: (1998) Parkinson's disease, pesticides and glutathione transferase polymorphisms. The Lancet 352, 1344-1346
McKinstry, WJ, Oakley, AJ, Rossjohn, J, Verger, D, Tan, K-L, Board, PG and Parker, MW: (1998) Preliminary X-ray crystallographic studies of a newly defined human theta-class glutathione transferase. Acta Crystalographica D54, 148-150
Nuccetelli, M, Mazzettia, AP, Rossjohn, J, Parker, MW, Board, P, Caccuri, AM, Federici, G, Ricci, G and Lo Bello, M: (1998) Shifting substrate specificity of human glutathione transferase (from class Pi to class Alpha) by a single point mutation. Biochemical and Biophysical Research Communications 252, 184-189
Rossjohn, J, McKinstry, WJ, Oakley, AJ, Verger, D, Flanagan, J, Chelvanayagam, G, Tan, K-L, Board, PG and Parker, MW: (1998) The crystal structure of human theta class glutathione transferase has a sulfate binding pocket within a buried site. Structure 6, 309-322
Tong, Z, Board, PG and Anders, MW: (1998) Glutathione transferase zeta-catalyzed biotransformation of dichloroacetic acid and other alpha-haloacids. Chemical Research in Toxicology 11, 1332-1338
Tong, Z, Board, PG and Anders, MW: (1998) Glutathione transferase zeta catalyzes the oxygenation of the carcinogen dichloroacetic acid to glyoxylic acid. Biochemical Journal 331, 371-374
Whitbread, L, Gali, RR, Board, PG: (1998) The structure of the human glutathione synthetase gene. Chemico-Biological Interactions 111-112, 35-40
Transplantation Immunology Laboratory
Simeonovic, CJ, Zarb, JC, Gazda, LS, Lafferty, KJ and Wilson, JD: (1998) Pancreatic islet and proislet transplantation in the mouse model. In: Microsurgical models in rats and mice for transplantation research. Timmermann, W, Ulrichs, K and Thiede, DA (eds). Springer-Verlag, Berlin,1998. pp 167 - 17
Simeonovic,CJ: (1998) Xenogeneicislet transplantation. Xenotransplantation. In press
Simeonovic, CJ, Townsend, MJ, Morris, CJ, Hapel, AJ, Fung, M-C, Mann, DA, Young, IG and Wilson, JD: (1998) Immune mechanisms associated with the rejection of fetal murine proislet allografts and pig proislet xenografts: Comparison of intragraft cytokine mRNA profiles. Transplantation. In press
Simeonovic, CJ, Townsend, MJ, Karupiah, G, Wilson, JD, Zarb, JC, Mann, DA and Young, IG: (1998) Analysis of the Th1/Th2 paradigm in transplantation: interferon-gamma-deficiency converts Th1-type proislet allograft rejection to a Th2-type xenograft-like response. Cell Transplantation. In press
Mucosal Inflammation and Cancer Group
Blackburn AC, Doe WF and Buffinton GD: (1998) Salicylate hydroxylation as an indicator of hydroxyl radical generation in dextran sulfate-induced colitis. Free Radic Biol Med 25, 305-313
Ferguson A, Campieri M, Doe W, Persson T and Nygard G (1998) Oral budesonide as maintenance therapy in Crohn’s disease--results of a 12-month study. Global Budesonide Study Group. Aliment Pharmacology Therapy 12:175-83
Kawasaki K, Hayashi Y, Wang Y, Suzuki S, Morita Y, Nakamura T, Narita K, Doe W, Itoh H and Kuroda Y (1998) Expression of urokinase-type plasminogen activator receptor and plasminogen activator inhiibitor-1 in gastric cancer. Journal of Gastroenterology and Hepatology 13:936-944
Suzuki S, Hayashi Y, Wang Y, Nakumura T, Morita Y, Kawasaki K, Ohta K, Aoyama N, Kim SR, Itoh H, Kuroda Y and Doe WF (1998) Urokinase type plasminogen activator receptor expression in colorectal neoplasms. Gut 43:798-805
Miller AM. Bassett ML, Dahlstrom JE and Doe WF (1998) Antiobiotic-associated haemorrhagic colitis. Journal of Gastroenterology and Hepatology 13:1115-1118
Ubiquitin Laboratory
Di Fruscio, M, Gilchrist, CA, Baker, RT, and Gray, DA (1998) Genomic structure of Unp, a murine gene encoding a ubiquitin-specific protease. Biochim. Biophys. Acta. 1398, 9-17
Kangsadalampai, S, Chelvanayagam, G, Baker, RT, Yenchitsomanus, P-T, Pung-amritt P, Mahasandana, C, and Board, PG (1998). A novel Asn344 deletion in the core domain of coagulation factor XIII A subunit: its effects on protein structure and function. Blood 92, 481-487
Baek, SH, Park, KC, Lee, JI, Kim, KI, Yoo, YJ, Tanaka, K, Baker, RT, and Chung, CH (1998) A novel family of ubiquitin-specific proteases in chick skeletal muscle with distinct N- and C-terminal extensions. Biochem. J 334, 677-684
Grayson H, Ellis JM, Chen S, Graham RM, Brown RD and Hill CE (1998) Immunohistochemical localisation of alpha1B adrenergic receptors in the rat iris. Cell and Tissue Res. 293, 435-444
Hong T and Hill CE (1998) Restricted expression of the gap junctional protein connexin 43 in the arterial system of the rat. Journal of Anatomy, 193,583-593
Hirst GDS, Edwards FR, Gould DJ, Sandow SL and Hill CE (1997) Electrical properties of irideal arterioles of the rat. American Journal of Physiology 273, H2465-H2472
Hill CE and Gould DJ (1997) Pathway specific effects of calcitonin gene-related peptide on irideal arterioles of the rat. J Physiol (Lond), 505, 797-809
Newhouse MJ and Hill CE (1997) A role for neuropeptide Y in rat irideal arterioles. American Journal of Physiology, 273, H2119-H2127
Phillips JK, McLean AJ and Hill CE (1998) Receptors involved in nerve-mediated vasoconstriction in small arteries of the rat hepatic mesentery. The British Journal of Pharmacology, 124, 1403-1412
Sandow SL, Whitehouse D and Hill CE (1998) Specialised neuroeffector associations in rat iris arterioles. Journal of Anatomy, 192, 45-57
Vidovic M and Hill CE (1997) Transient expression of -1B adrenoceptor messenger ribonucleic acids in the rat superior cervical ganglion postnatal development. Neuroscience, 77, 841-848
Cellular Neurophysiology
Mahanaty NK and Sah P (1998) Calcium-permeable AMPA receptors mediate long-term potentiation in interneurons in the amygdala. Nature, 394, 683-687
Margrie TW, Rostas JAP and Sah P (1998) Presynaptic long-term depression at a central glutamatergic synapse: a role for CaMK11. Nature Neuroscience, 1, 378-383
Mahanty NK and Sah P (1999) Excitatory synaptic inputs to pyramidal neurons of the lateral amygdala. European Journal of Neuroscience. In press
Sah P and Clements JD (1999) Photolytic manipulation of [Ca2+]i reveals slow kinetics of potassium channels underlying the afterhyperpolarisation in hippocapmal pyramidal neurons Journal of Neuroscience. In press
Developmental Neurobiology Group
Reynolds AJ, Bartlett SE & Hendry IA (1998). Signalling events regulating the retrograde axonal transport of 125I- beta nerve growth factor in vivo. Brain Research, 798, 67-74
Kelleher KL, Matthaei KI, Leck KJ & Hendry IA (1998). Developmental expression of messenger RNA levels of the alpha subunit of the GTP-binding protein, Gz, in the mouse nervous system. Developmental Brain Research, 107, 247-253
Bartlett SE (1997).Protein tyrosine kinase inhibitors synergize with nerve growth factor in embryonic chick sensory neuronal cell survival. Neuroscience Letters, 227, 87-90
Bartlett SE & Hendry IA (1997). Identifying the G protein, Gz alpha, and its associated proteins in nervous tissue using mass spectrometry and microsequencing techniques. Int.J Dev.Neurosci. 15, 267-274
Bartlett SE (1998). Identifying Proteins in Nervous Tissue using Microsequencing Techniques. In Neurotrophin and Receptor Methods and Protocols, ed. RUSH, RA, New Jersey: Humana Press Inc.
Molecular Signalling
Johanson SO, Naccache PA and Crouch MF A p85 subunit-independent p110 alpha PI 3-kinase colocalizes with p70 S6 kinase on actin stress fibres and regulates thrombin-stimulated stress fibre formation in Swiss 3T3 cells. Experimental Cell Research . In press
Synaptic Biophysics
Bekkers JM (1998) Are autapses prodigal synapses? Current Biology, 8, R52-R55.
Reid CA, Bekkers JM & Clements JD (1998) N-type and P/Q-type Ca2+ channels mediate transmitter release with a similar cooperativity at rat hippocampal synapses.Journal of Neuroscience, 8, 2849-2855
Bekkers JM (1998) Strontium-evoked mEPSCs reveal large quantal variance at central glutamate synapses. In: Central synapses: quantal mechanisms and plasticity, D Faber, H Atwood, H Korn, S Redman, S Thomson & J Altman (eds) (Human Frontier Science Program, Strasbourg), pp 115-123
Synaptic Biochemistry
Morgans CW, El Far O, Berntson A, Wässle H and Taylor WR (1998) Calcium extrusion from mammalian Photoreceptor terminals, Journal of Neuroscience, 18, 2467-2474
Synaptic Structure and Function Group
Bellingham MC (1998) Driving respiration - the central respiratory pattern generator. Clinical and Exp Pharmacol Physiol 25:847-856
Bellingham MC, Lim R and Walmsley B (1998) Developmental changes in EPSC quantal size and quantal content at a central glutamatergic synapse in rate. Journal of Physiology, 511(3), 861-869
Walmsley B, Alvarez FJ and Fyffe REW (1998) Diversity of structure and function at mammalian central synapses. Trends in Neurosciences, 21(2), 81-88
Walmsley B and Nicol MJ (1998) Modulation of action potentials and Clarke's column of the spinal cord. In Presynaptic Inhibition and Neural Control. Eds. L Mendell, P Rudomin and R Romo. Oxford University Press. Pp. 138-149.
Walmsley B (1998) Signalling at the synapse: Regulation of the post-synaptic response to quantal transmitter release. Immunology and Cell Biology, 76, 430-435
Synaptic Transmission Group
Cowan A, Stricker C, Reece LJ and Redman SJ (1997) Long-term plasticity at excitatory synapses on aspinous interneurones in area CA1 lacks synaptic specificity. J Neurophysiol. 79, 13-20
Curtis DR and Lacey G (1998) Prolonged GABA-B recedptor-mediated synaptic inhibition in the cat spinal cord: an in vivo study. Experimental Brain Research, 3, 319-333
Curtis DR and Lacey G Baclofen: lack of effect on spinal motor axon collateral termination acction potentials in vivo. Experimental Brain Research. In press
Clements JD, Feltz A, Sahara Y and Westbrook GL (1998) Activation kinetics of AMPA channels reveal number of functional agonist binding sites. Journal of Neuroscience, 18, 119-127
Clements JD (1998) AxoGraph 4.0. This upgrade adds data acquisition with online analysis, and chemical kinetic modelling and analysis. Copyright, JD Clements. Distributed by Axon Instruments, Inc.
Schiller J, Schiller Y, Stuart G and Sakmann B (1997) Calcium action potentials restricted to the distal apical dendrites of rat neocortical pyramidal neurons. Journal of Physiology, 505, 605-616
Stuart G and Spruston N (1998) Determinants of voltage attenuation in neocortical pyramidal neuron dendrites. Journal of Neuroscience, 18, 3501-3510
Stuart G Voltage-activated sodium channels amplify inhibition in neocortical pyramidal neurons. Nature Neuroscience. In press
Thurbon D, Lüscher H-R, Hofstetter T & Redman SJ (1998) Passive, electrical properties of ventral horn neurons in rat spinal cord slices. J Neurophysiol. 79, 2485-2502
Visual Neurosciences Group
Taylor WR, Morgans C : (1998) Localization and properties of voltage-gated channels in cone photoreceptors of Tupaia belangeri . Visual Neuroscience, 15, 541-552