Collaboration

Centre for Bioinformation Science

Prof S Easteal

The Centre for Bioinformation Science (CBiS) had a very busy inaugural year. CBiS was founded through a budget allocation from the Institute of Advanced Studies Planning Committee to the John Curtin School of Medical Research and the School of Mathematical Sciences. Simon Easteal and Sue Wilson from JCSMR and SMS respectively were appointed as co-Directors and CBiS has a presence in both Schools. The purpose of the Centre is to bring together expertise in mathematics, statistics, information science and quantitative biology to investigate how information contained in genomes contributes to the development and functioning of organisms and to individual differences. Research activities included: the development of novel approaches to sequence alignment, protein structure prediction, protein evolution analysis, gene expression analysis and gene interaction effects in disease. More information

 

Dr R Baker

Ubiquitin-specific proteases in cancer
Associate Prof D A Gray
Ottawa Regional Cancer Centre, University of Ottawa, Ottawa, Ontario, Canada

Phylogenetic and structural studies of the ubiquitin-specific protease family
Dr LS Jermiin
School of Biological Sciences, University of Sydney, Sydney NSW

Chromosomal mapping of human genes
Dr G Sutherland and Mrs E Woolatt
Dept of Cytogenetics and Molecular Genetics, Women’s and Children’s Hospital, Adelaide SA

 

Dr J Banyer

Determination of genetic factors responsible for multi-drug resistance in small cell lung carcinoma
Dr R Davey
Clinical Oncology, Royal North Shore Hospital, Sydney, NSW


Ross River Virus persistent infection of macrophages: A model of viral relapse
Dr B Lidbury, University of Canberra, Canberra, ACT


Effects of Hepatitis C infection on the immunoregulatory properties of monocyte derived dendritic cells
Dr R Ffrench
Westfield Reserch Laboratories, Sydney Childrens Hospital, Sydney, NSW

Effects of Hepatitis C on the immunoregulating properties of human OC subsets
Dr E Maraskovsky
Ludwig Institute, Melbourne, Vic




Prof P Board

Structural analysis of glutathione S-transferases
Dr M Parker
St Vincents Medical Research Institute, Melbourne, Vic

Regulation of mouse Theta class GST genes
Dr W Pearson
Department of Biochemistry, School of Medicine, University of Virginia Health Sciences Center, Charlottesville, Virginia, USA

Structural analysis of the Omega class GSTs
Dr C Gabel, Dr K Geoghegan and Dr J Pandit
Central Research Division, Pfizer Inc, Groton, CT, USA

Phylogenetic and evolutionary studies of the glutathione S-transferase family
Dr LS Jermiin
School of Biological Sciences, University of Sydney

Parkinson's Disease, Pesticides and glutathione transferase polymorphisms
Dr D LeCouteur
Department of Pharmacology, University of Sydney and Canberra Clincal School, The Canberra Hospital

Function of the Zeta class GSTs
Dr MW Anders
Dept of Pharmacology and Physiology, University of Rochester Medical School

Functional analysis of glutathione transferases
Drs M Lo Bello, A Caccuri and G Ricci
University of Rome

Metabolism of arsenic by glutathione transferases
Dr H V Aposhian
Dept of Molecular and Cellular Biology, University of Arizona, USA

Glutathione transferases and drug toxicity
Dr L Rivory
Sydney Cancer Centre

 

Dr MG Casarotto

Structural studies into the mechanism of dihydrofolate reductase
Prof G Roberts
Centre for Mechanisms of Human Toxicity, University of Leicester, UK
Dr J Basran
Department of Biochemistry, University of Leicester, UK

Chitinase and Chitin Binding Proteins
Dr C Vorgias
Biology Department, Athens University, Greece
Prof H Schrempf
Universitat Osnabruk, FB Biologie/Chemie, Osnabruk, Germany

Peptide activators of the ryanodine receptor
Prof I Toth
Pharmacy Department, University of Queensland

Effects of drugs that block Vpu ion channels studied with NMR techniques
Prof T Watts
Biomembrane Structure Unit, University of Oxford




Dr B Charlton

The role of NO in regulation of EAE
Dr D Willenborg
The Canberra Hospital, Canberra, ACT

The effect of Fas-Fas ligand interaction on diabetes in NOD mice
Dr N Petrovsky
The Canberra Hospital, Canberra, ACT

 

Dr P Cooper

Adjuvant activity of gamma inulin
Dr P Fuentes
Universitat Autonoma de Barcelona, Barcelona, Spain
Dr G Guillen
Centre for Genetic Engineering & Biotechnology, Havana, Cuba
Dr DO Willenborg
Neurosciences Research Unit,The Canberra Hospital, Canberra, ACT
Prof G Tannock
Royal Melbourne Institute of Technology, Melbourne, Vic
Prof A Erdei
Dept of Immunology, Eotvos Lorand University, Göd, Hungary

Dr E Riviere
Intervet Pharma R&D, Beaucouzè, France

Dr N Petrovsky
National Health Sciences Centre, The Canberra Hospital

 

Dr WB Cowden

The role of nitric oxide in infectious and autoimmune disease
Dr K Rockett
Institute of Molecular Medicine, Oxford, UK

The role of free radicals in vascular disease
Dr R Stocker
The Heart Research Institute, Sydney, NSW

The activity and mechanism of action of novel glycoprotein processing inhibitor anti-rejection agents
Prof A Hibberd
Hunter Valley Hospital Transplant Unit, Newcastle, NSW

 

Prof AF Dulhunty

Oxidation of ryanodine receptor from malignant hyperthermic pig muscle
Prof R Fink
University of Heidelberg, Heidelberg Germany

Structure of DHPR binding domain on ryanodine receptor calcium release channel
Prof D McClennan
Banting & Best Research Institute, Toronto, Canada
Prof Y Ogawa
Juntendo University School of Medicine, Tokyo, Japan

Effects of ryanodine receptor activation
Dr D R Laver
BAMBI, ANU

Activation of malignant hyperthermic pig muscle
Prof E Gallant
University of Minnesota, USA

Bioavailability of peptides that activate ryanodine receptors
Prof I Toth and Dr P Mollinar
University of Queensland

Structure of ryanodine receptors
Dr M Parker
St Vincents Institute of Medical Research, Melbourne

Actions of peptides on skinned muscle fibres
Dr G Lamb
La Trobe University

 

Prof S Easteal

The genetic basis of common mental disorders associated with anxiety and depression
Prof A Jorm
Social Psychiatry Research Unit, ANU
Prof Margot Prior
Psychology Department, Melbourne University




Dr P Foster

The characterization of the role of eotain in the mechanism of pulmonary eosinophilic inflammation
Dr M Rothenberg
Childrens Hospital Medical Centre, University of Cincinnati, USA

The role of IL-13 in asthma
Dr A Mackenzie
Cambridge University

Models of chronic asthma
Dr Kumar
University of NSW

 

Prof PW Gage

Effects of conotoxins on sodium currents
Prof D Adams
Department of Physiology and Pharmacology, University of Queensland

Structure of the GABAA receptor
Dr M Parker
St Vincents Institute of Medical Research, Melbourne

Effects of drugs that block Vpu ion channels on HIV-1 replication
Prof T Cunningham and Dr H Naif
Westmead Hospital, NSW

Structure of Vpu ion channels studied with NMR techniques
Prof T Watts
Oxford, UK



Dr C Freeman

Cleavage of heparan sulphate by mammalian heparanase
Dr J Turnbull
Molecular Cell Biology Laboratory, School of Biosciences, University of Birmingham, Edgbaston, UK

Sequencing the heparanase cleavage site of heparan sulphate
Drs D Coombe and W Kett
Molecular Immunology Laboratory, School of Biomedical Sciences, Curtin University of Technology, Perth, WA

Heparanase activity in post-operative vascular surgery patients
Dr J Bingley
Princess Alexandra Hospital, Brisbane, Qld

Heparanase activity in bone marrow extracts following hematopoietic progenitor cell mobilisation
Dr J-P Levesque
Stem Cell Biology Laboratory, Peter MacCallum Cancer Institute, Melbourne, Vic

Heparanase activity in mucopolysaccharidosis patients
Prof J Hopwood
Adelaide Women’s and Children’s Hospital, Adelaide, SA

Heparanase activity in myeloma cells
Dr O Hjertner
Institute of Cancer Research and Molecular Biology, Medisinsk Teknisk Senter, Trondheim, Norway

A novel method to sequence heparan sulphate
Drs J McLeod and P Grace
Research School of Chemistry, ANU




Prof C Goodnow

Gene expression profiles of memory B cells and diabetic islets
Dr M Cooke
Genome Institute of The Novartis Foundation, San Diego CA

Genetic modifiers of squamous carcinogenesis
Dr D Hanahan
University of California, San Francisco
Dr S Foote
WEHI, Melbourne

Identification of ENU-induced mutations causing hematopoietic abnormalities
Drs D Hilton and W Alexander
WEHI, Melbourne

Identification of ENU-induced mutations causing bone density defects
Dr E Gardiner
Garvan Institute, Sydney

Identification of ENU-induced mutations causing abnormal breast duct growth
Dr C Ormandy
Garvan Institute, Sydney

Gene mapping, gene expression profiling and protein profiling of mouse mutation on an array of arrays
Dr M Chee
Illumina, Inc, San Diego

Analysis of ENU-induced neurological mutations
Dr C Fletcher
Genome Institute of The Novartis Foundation, San Diego, CA

Role of Ikaros in erythropoiesis
Dr A Perkins
Monash University

Genetics and hormonal effects on pancreatic islet B cell failure
Dr N Petrovsky
The Canberra Hospital

Control of humoral immunity
Dr M Cook
The Canberra Hospital

 

Dr J Gready

Use of NMR to study liver dysfunction in cirrhosis
Prof AJ McLean, Dr PJ Harvey, Dr L Lenton and Mr M Taylor
Canberra Clinical School, University of Sydney
Prof PW Kuchel, Dr S Ramadan and Dr W Bubb
Dept of Biochemistry, University of Sydney
Prof D Le Couteur
Centre for Education and Research on Ageing, Concord Hospital NSW

Development and application of sensitive protein sequence analysis methods
Dr H Booth
Centre for Bioinformation Science, School of Mathematics

Development and application of improved force fields for protein simulations
Assoc Prof K Sagarik
Suranaree University of Technology, Thailand
Ms P Sisot
Ramkhamhaeng University, Thailand


Dr JE Gready, Dr PL Cummins and Dr H Mauser

Development of methods and applications for biomolecular QM/MM calculations
Dr I Rostov
ANU Supercomputer Facility
Dr A Rendell
Department of Computer Science, FEIT
Dr D Jayatilaka
Research School of Chemistry, ANU


Dr JE Gready, Dr PL Cummins and Mr SJ Titmuss

Development, evaluation and application of the linear-scaling QM method MOZYME for biomolecular calculations
Dr A Bliznyuk
ANU Supercomputer Facility
Dr A Rendell
Department of Computer Science, FEITDr R Nobes
Fujitsu European Centre for Information Technology, London, UKDr J Stewart
Stewart Computational Chemistry, Colorado Springs, USA

Comparison of semiempirical and ab initio QM intermolecular interaction energies
Dr A Bliznyuk
ANU Supercomputer Facility
Dr D Jayatilaka
Research School of Chemistry, ANU
Dr A Rendell
Department of Computer Science, FEIT


Dr JE Gready, Ms M Gustiananda and Dr P Milburn

FTIR studies of prion protein repeats
Dr P Haris
De Montfort University, Leicester UK

 

Dr JE Gready and Dr H Mauser


Computational studies of the catalytic mechanism
of the photosynthetic enzyme, Rubisco
Prof TJ Andrews
Molecular Plant Physiology Group, RSBS


Dr J Gready and Mr A Zelensky

Structural and functional evolution of extracellular proteins
Dr Y Matsuo and Dr F Pichierri
RIKEN Genomic Sciences Center, Yokohama, Japan



Prof IA Hendry

Nerve Growth Factor retrograde axonal signalling may be modified by PI 3-kinase dependent protein associations at the nerve terminal including Centaurin-1 and Arf6 Divergent pathways linked to PH-domains explain varied roles of PI3-kinase in neurons

Dr T Cowen
Department Anatomy and Developmental Biology, Royal Free and University College Medical School, Royal Free Campus, London

Neuromuscular growth factors role of TGF-beta and GDNF in motoneurone survival and death
Dr Ian McLennan
Department of Anatomy, University of Otago



Dr C Hill

Cell-cell communication in the wall of mouse mesenteric arteries
Prof C Garland and Dr K Dora
University of Bath, UK

Gap junctions; the critical link in EDHF action
Drs H Parkington, H Coleman, M Tare
Monash University




Dr M Hulett

Molecular mechanisms of cell invasion and angiogenesis
Prof CN Chesterman, Prof BH Chong, Assoc Prof PJ Hogg, Dr LM Khachigan
University of New South Wales, Sydney, NSW
Dr RK Andrews and Prof MC Berndt
The Baker Medical Research Institute, Melbourne, Vic

Cloning and characterisation of a novel family of tetraspan molecules
Dr L Baker and Prof G Sutherland
The Womens and Childrens Hospital, Adelaide, SA
Prof PM Hogarth
The Austin Research Institute, Melbourne, Vic
Ms L Maxwell
The Canberra Hospital, Canberra, ACT



Dr G Huttley

Bioinformatics of the Kangaroo Genome Project
Dr M Wakefield, Prof J Graves
Comparative Genomics Group, Research School of Biological Sciences, ANU

Evolution of DNA repair genes, and population genetics of tumour suppressor genes
Prof L Nunney,
Dept Biology
Prof M Ragan
Institute for Molecular Bioscience, University of Queensland

Exploring the roots to the tree of life
Dr A Isaev
Moscow State University

The genetics of melanocortin receptor-1 gene
Dr R Sturm
Institute for Molecular Bioscience, University of Queensland



Prof DA Jans


The cell-specific delivery of DNA or photosensitiser molecules to the nucleus of target cells
Prof AS Sobolev
Russian Institute for Agricultural Biotechnology, Moscow

The mechanism of nuclear transport and role in infection of the NS5 polymerase protein of Dengue virus
Dr S Vasudevan
Dept of Biochem & Mol Biol, James Cook University of North Queensland

Nuclear targeting of the serine protease granzyme B in cytolytic granule mediated apoptosis
Drs JA Trapani and V Sutton
Peter MacCallum Cancer Research Institute, Melbourne

Nuclear transport and function of the granzyme B inhibitor, the serpin PI-9
Dr PI Bird
Dept of Medicine, Monash University

Calmodulin regulated NLSs in proteins important in testis development
Dr K Loveland
Institute for Reproduction and Development, Melbourne
Dr V Harley
Prince Henry's Hospital, Melbourne

Nuclear import and actions of insulin-like growth factor binding protein-3 (IGFBP-3) and IGFBP-5
Dr L Schedlich and Prof R Baxter
Kolling Research Institute, Sydney

Nuclear signalling pathway of Ern1p in the unfolded protein response in yeast
Prof M-G Gething
Dept Biochem and Biophysics, University of Melbourne

Development of chimeric proteins for targeted gene delivery
Dr R Nordon
Biomed-Engineering, University of NSW

Anti-AIDS virus Strategies
Prof A Loyter
Alexander Silberman Institute of Life Sciences, Jerusalem



Dr M Lobigs

Protective immune responses in mice against Japanese encephalitis virus and infection-enhancing serocomplex flaviviruses
Dr RA Hall and Prof J Mackenzie
Department of Microbiology, University of Queensland, Brisbane, Qld

Modulation of the MHC class I antigen processing and presentation pathway by flaviviral infection
Dr F Momburg
German Cancer Research Center, Heidelberg, Germany



Dr KI Matthaei

The control of inflammatory disease in vivo
Dr S Breit
Centre for Immunology, St Vincents Hospital, Darlinghurst, Sydney, NSW

The role of mast cells in vivo

Prof S Krilis
Department of Immunology, Allergy & Infectious Diseases, The St George Hospital, Kogarah NSW 2217

Murine filariasis infections in cytokine deficient mice
Prof A Hoerauf
Department of Helminthology, Bernhard Nocht Institute of Tropical Medicine, Hamburg, Germany




Dr P McCullagh


Investigation of X maturation of the ileal Peyers patches
Prof C Press and T Landsverk
Royal Norwegian Veterinary School, Oslo

Development of Peyers patches and of immunological function in the gut of the fetal lamb
Dr S McClure
McMaster Laboratory, CSIRO, Sydney

Compartmental modelling of lymphocyte migration
Dr L Dedik
Faculty of Mechanical Engineering, Slovak Technological University, Bratislava

Compartmental modelling of lymphocyte migration
Dr M Durisova
Institute of Experimental Pharmacology, Slovak Academy of Sciences, Bratislava

System analysis of lymphocyte migration
Dr F De Bruyne
Research School of Engineering and Information Science, ANU

Pulmonary development in thyroidectomized fetal lambs
Dr M Peek
Fetal Medicine Unit, Department of Obstetrics, University of Sydney, Canberra Clinical School

Electron microscopic examination of the alveoli of athyroid fetal lambs
Dr J Dahlstrom
Pathology Department, The Canberra Hospital

Colonization of Peyers patches by Mycobacterium avium complex
Dr R Whittington
Elizabeth Macarthur Institute



Dr C Morgans


Effect of deletion of the beta-2 calcium channel subunit on transmisssion between photoreceptors and the inner retina in mouse
Dr R Gregg
University of Louisville, Louisville, KY
Dr S Ball
Cleveland VA Medical Center, Cleveland, OH



Dr A M
üllbacher

Oral induced T cell tolerance

Dr J Chin
Elizabeth MacArthur AG Institute, NSW Department of Agriculture, Camden, NSW

The role of granzyme A in fungal infection
Dr R Ashman
Oral Biology and Pathology, University of Queensland, Brisbane, Qld

The role of granzymes in herpes virus infection
Drs R Pereira and A Simmons
Herpes Research, Infectious Diseases Laboratories, Institute of Medical & Veterinary Science, Adelaide, SA

The role of granzymes in viral infection
Dr M Smyth
Peter MacCallum Cancer Centre, Melbourne, Vic

The granzymes in early defence against viral infection
Dr J Trapani
Peter MacCallum Cancer Centre, Melbourne, Vic

The role of granzymes in the induction of apoptosis
Dr M Simon
Max Planck Institute für Immunbiologie, Freiburg, Germany

Apoptosis in the cellular immune response
Dr P Waring
Department of Chemistry, The Faculties, ANU

The role of poxvirus encoded serpins in cytotoxic T cell induced apoptosis
Dr R Wallich
Department of Immunology, University of Heidelberg, Heidelberg, Germany



Drs A Müllbacher & M Lobigs

The role of T cell serine proteases in cell cytotoxicity and viral pathogenesis
Dr M Simon
Max Planck Institute für Immunbiologie, Freiburg, Germany

Allorecognition
Dr R Langman
Conceptual Immunology, The Salk Institute, La Jolla, CA, USA

Hep C and liver damage
Assoc Prof ML Bassett
Gastroenterology Unit, The Canberra Hospital, Canberra, ACT



Prof C Parish

Role of histidine-rich glycoprotein in angiostatin formation and action
Dr P Hogg and Prof C Chesterman
School of Pathology, University of New South Wales, Sydney, NSW
Dr J Altin
Biochemistry and Molecular Biology Division, The Faculties, ANU

Role of platelets in tumour metastasis
Dr M Berndt
Baker Research Institute, Melbourne, Vic

Novel complement activation pathways
Prof M Walport and Dr M Botto
Imperial College School of Medicine, London, UK

Analysis of cell adhesion molecules on human lymphocytes
Dr H Warren
The Canberra Hospital, Canberra, ACT

Novel multimeric technology for cell surface molecules
Dr J Altin
Biochemistry and Molecular Biology Division, The Faculties, ANU

Eosinophil-induced tumour regression
Dr M Rothenberg
University of Cincinnati, Cincinnati, USA

Sulfated oligosaccharides as anti-viral agents
Dr A Cunningham
Westmead Hospital, Sydney, NSW



Prof C Parish and Dr C Freeman


Development of pseudo-oligosaccharides as heparan sulfate mimetics
Prof M Banwell and Dr D Armitt
Research School of Chemistry, ANU



Prof C Parish, Drs C Freeman and M Hulett

3D structure of mammalian heparanase
Dr M Parker
St Vincents Hospital, Melbourne, VIC

Heparanase as an anti-tumour target
Dr R Anderson
Peter MacCallum Cancer Institute, Melbourne, VIC
Drs H Wheeler and N Pavlakis
Royal North Shore Hospital, Sydney, NSW

Heparanase as an anti-tumour target
Drs J Joyce and D Hanahan
Hormone Research Unit, University of California at San Francisco, California, USA


Prof SJ Redman

Role of spinal interneurons in control of movement

Dr T Jessell
Columbia University, New York
Dr M Goulding
Salk Laboratories, San Diego
Dr L Ziskin-Conhaim
University of Wisconsin, Madison

Serial correlation in transmitter release
Drs C Stricker and A Cowan
Neuroinformatics Institute, Zurich




Dr P Sah

Properties of glycine receptors

Dr R Callister
Department of Anatomy, University of Newcastle

Recordings from GSP-positive neurons in brain slices
Dr S Hestrin
Department of Comparative Anatomy, Stanford University



Dr MF Shannon


Role of chromatin architectural proteins in cytokine gene transcription
Dr R Reeves
Washington State University, USA

The role of chromatin remodeling in the development of effector and memory T cells in an immune response
Dr G Stockinger
National Institute of Medical Research, London

The role of c-Rel in CD28 signaling in T cells
Dr S Gerondakis
WEHI, Melbourne



Dr CJ Simeonovic

Regulation of pig proislet xenograft destruction and assessment of the potential for xenozoonoses
Prof A Gibbs
Molecular Genetics and Evolution, Research School of Biological Sciences, ANU
Clin Assoc Prof JD Wilson
Department of Endocrinology, The Canberra Hospital, Canberra, ACT

Role of chemokines in the rejection of pig proislet xenografts
Dr WA Kuziel
Section of Molecular Genetics and Microbiology, The University of Texas at Austin, Austin, Texas, USA


Dr RM Slattery

T Cell populations in b2Ma vs b2Mb transgenic NOD mice
Dr Dale Godfrey
Monash University, Melbourne



Dr G Stuart

Interaction of action potentials with synaptic events
and
The role of IH in spontaneous firing in cerebellar
Purkinje neurons
Dr M Hausser
University College, London

Dendritic coupling in the VTA and its role in interhemispheric switching
Prof J Pettigrew
University of Queensland



Dr SA Thomson


HIV Clinical trials
Australian HIV Vaccine Consortium (Head Dr D Cooper), Nat Centre for Epidemiology and Clinical Research, University of New South Wales, Sydney, NSW

HIV SAVINE
D Fuller
PowderJect (USA), Madison, Wisconsin, USA
Dr S Kent
Department of Microbiology, University of Melbourne, Melbourne, VICDr RA Ffrench
Pediatric Research Labs, Sydney Children’s Hospital, Westmead, NSW

Hepatitis C SAVINE
Dr RA Ffrench
Pediatric Research Labs, Sydney Children’s Hospital, Westmead, NSW

Assoc Prof B Rawlinson
Prince of Wales Hospital, Randwick, NSW

Prof A Lloyd
Department of Infectious Diseases, Prince of Wales Hospital, Randwick, NSW


Tuberculosis SAVINE

Prof W Britton and Dr C Demangel
Centenary Institute, Camperdown, NSW

Papilloma virus and cervical cancer polyepitope vaccine
Assoc Prof B Tindle
Sir Albert Sakzewski Virus Research Centre, Brisbane Qld

Nasopharyngeal carcinoma polyepitope
Dr R Khanna
Queensland Institute of Medical Research, Brisbane Qld



Dr DJ Tremethick

Function of histone H2AZ in mammalian development
Dr I Lyons
Department of Biochemistry, University of Adelaide, SA

Solving the crystal structure of an H2AZ containing nucleosome
Dr K Luger
Department of Biochemistry and Molecular Biology
Colorado State University, USA

To examine a possible link between the mode of action of Phenobarbital and chromatin structure
Dr B May
Department of Biochemistry, University of Adelaide, SA

Gaining an understanding of the role of chromatin in the regulation of hepatitis B virus (HBV) gene expression and pathogenesis
Dr J Fyfe
Victorian Infectious Disease Resource Laboratory, VIC

Determining whether H2AZ alters higher order chromatin folding
Dr J Hansen
Department of Biochemistry, The University of Texas Health Sciences Center, San Antonio



Prof JA Whitworth


Dr D Torpy
Department of Medicine, University of Queensland

Prof B Morris
Department of Physiology, University of Sydney

Assoc Prof J Kelly
Department of Medicine, St George Hospital, University of New South Wales

Dr G Mangos
Department of Medicine, St George Hospital, University of New South Wales




Prof IG Young and Dr K Matthaei

The role of IL-5 in smooth muscle hyperreactivity of the gut
Prof S Collins
Division of Gastroenterology, McMaster University, Department of Medicine, Hamilton, Ontario, Canada

The role of IL-5 and eosinophils in allergy
Dr M Rothenberg
Division of Pulmonary Medicine, Allergy & Immunology, Childrens Hospital Medical Centre, Cincinnati, Ohio, USA

The role of IL-5 in eosinophil precursor differentiation
Prof J Denburg
Department of Medicine, McMaster University, Hamilton, Ontario, Canada

The role of the mouse homologues of “flightless” and “sol” in vivo
Dr H Campbell
Molecular Evolution and Systematics, RSBS, ANU