JCSMR Annual Report 2003 - John Curtin School of Medical Research

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Publications 2003

1. Ada, G., 2003, Progress towards achieving new vaccine and vaccination goals. Internal Medicine Journal 33(7), 297-304.

2. Ada, G., 2003, Overview of vaccines. 2nd ed. Methods in Molecular Medicine - Vaccine Protocols, eds. A. Robinson, M. Cranage, and M. Hudson, New Jersey: The Humana Press, Inc. pp. 1-17.

3. Ada, G. and Isaacs, D., 2003, Carbohydrate-protein conjugate vaccines. Clinical Microbiology and Infection 9(2), 79-85.

4. Ada, G. and Ramshaw, I., 2003, DNA Vaccination. Expert Opinion on Emerging Drugs 8, 27-36.

5. Alitheen, N., McClure, S., and McCullagh, P., 2003, Development of B cells in the gut-associated lymphoid tissue of mid-gestational fetal lambs. Developmental and Comparative Immunology 27(6-7), 639-646.

6. Angelats, C., Wang, X.W., Jermiin, L.S., Copeland, N.G., Jenkins, N.A., and Baker, R.T., 2003, Isolation and characterization of the mouse ubiquitin-specific protease Usp15. Mammalian Genome 14(1), 31-46.

7. Armarego, W.L.F., Chai, C.L.L, 2003, Purification of Laboratory Chemicals. 5th ed: Elsevier Science (USA). pp. 609 pp.

8. Baharvand, H. and Matthaei, K.I., 2003, The ultrastructure of mouse embryonic stem cells. Reproductive BioMedicine Online 7(3), 330-335.

9. Banwell, M.G., Bezos, A., Chand, S., Dannhardt, G., Kiefer, W., Nowe, U., Parish, C.R., Savage, G.P., and Ulbrich, H., 2003, Convergent synthesis and preliminary biological evaluations of the stilbenolignan (+/-)-aiphanol and various congeners. Organic & Biomolecular Chemistry 1(14), 2427-2429.

10. Banyer, J.L., Halliday, D.C.T., Thomson, S.A., and Hamilton, N.H.R., 2003, Combinations of IFN-gamma and IL-4 induce distinct profiles of dendritic cell-associated immunoregulatory properties. Genes and Immunity 4(6), 427-440.

11. Bassett, M.L., Dahlstrom, J.E., Taylor, M.C., Koina, M.E., Maxwell, L., Francis, D., Jain, S., and McLean, A.J., 2003, Ultrastructural changes in hepatic sinusoidal endothelial cells acutely exposed to colloidal iron. Experimental and Toxicologic Pathology 55(1), 11-16.

12. Bath, P., Chalmers, J., Powers, W., Beilin, L., Davis, S., Lenfant, C., Mancia, G., Neal, B., Whitworth, J., and Zanchetti, A., 2003, International Society of Hypertension (ISH): Statement on the Management of Blood Pressure in Acute Stroke. Journal of Hypertension 21, 665-672.

13. Bekkers, J.M., 2003, Convolution of mini distributions for fitting evoked synaptic amplitude histograms. Journal of Neuroscience Methods 130(2), 105-114.

14. Bekkers, J.M., 2003, Synaptic transmission: Functional autapses in the cortex. Current Biology 13(11), R433-R435.

15. Berntson, A. and Taylor, W.R., 2003, The unitary event amplitude of mouse retinal on-cone bipolar cells. Visual Neuroscience 20(6), 621-626.

16. Berntson, A., Taylor, W.R., and Morgans, C.W., 2003, Molecular identity, synaptic localization, and physiology of calcium channels in retinal bipolar cells. Journal of Neuroscience Research 71(1), 146-151.

17. Berntson, A.K. and Morgans, C.W., 2003, Distribution of the presynaptic calcium sensors, synaptotagmin I/II and synaptotagmin III, in the goldfish and rodent retinas. Journal of Vision 3, 274-280.

18. Blackburn, A.C., Brown, J.S., Naber, S.P., Otis, C.N., Wood, J.T., and Jerry, D.J., 2003, BALB/c alleles for Prkdc and Cdkn2a interact to modify tumor susceptibility in Trp53+/- mice. Cancer Research 63, 2364-2368.

19. Board, P.G., Taylor, M.C., Coggan, M., Parker, M.W., Lantum, H.B., and Anders, M.W., 2003, Clarification of the role of key active site residues of glutathione transferase Zeta/maleylacetoacetate isomerase by a new spectrophotometric technique. Biochemical Journal 374, 731-737.

20. Booth, H.S., Maindonald, J.H., Nielson, O.M., and Wilson, S.R., 2003, Standardization of Sequence Alignment Scores. Proceedings of the APAC Conference and Exhibition on Advanced Computing, Grid Applications and eResearch (APAC'03).

21. Breman, J.G., Arita, I., and Fenner, F., 2003, Preventing the return of smallpox. New England Journal of Medicine 348(5), 463-466.

22. Brusic, V., Millot, M., Petrovsky, N., Gendel, S.M., Gigonzac, S., and Stelman, S.J., 2003, Allergen Databases. Allergy 58(11), 1093-1100.

23. Brusic, V. and Petrovsky, N., 2003, Immunoinformatics. Immunoinformatics: Bioinformatic Strategies for Better Understanding of Immune Function. 254: Novartis Found Symp. pp. 3-13 discussion 13-22, 98-101, 250-252.

24. Brusic, V. and Petrovsky, N., 2003, Bioinformatics for Characterisation of Allergens, Allergenicity and Allergic Cross-Reactivity. Trends in Immunology 24, 225-228.

25. Brusic, V., Petrovsky, N., Gendel, S.M., Millot, M., Gigonzac, S., and Stelman, S.J., 2003, Computational Tools for the Study of Allergens. Allergy 58(11), 1083-1092.

26. Brusic, V., Pillai, R.S., Silva, D.G., Petrovsky, N., and Schonbach, C., 2003, Cytokine-related genes identified from the RIKEN full-length mouse cDNA data set. Genome Research 13(6B), 1307-1317.

27. Cavanaugh, J.A., Adams, K.E., Quak, E.J., Bryce, M.E., O'Callaghan, N.J., Rodgers, H.J., Magarr, G.R., Butler, W.J., Eaden, J.A., Roberts-Thomson, I.C., Pavli, P., Wilson, S.R., and Callen, D.F., 2003, CARD15/NOD2 risk alleles in the development of Crohn's disease in the Australian population. Annals of Human Genetics 67, 35-41.

28. Chalmers, J., Beilin, L., Mancia, J., Whitworth, J., and Zanchetti, A., 2003, International Society of Hypertension (ISH): statements on blood pressure and stroke. Journal of Hypertension 21(4), 649-650.

29. Chalmers, J., Todd, A., Chapman, N., Beilin, L., Davis, S., Donnan, G., Frommer, M., Huxley, R., Lenfant, C., Macmahon, S., Mancia, G., Mendis, S., Whitworth, J., and Zanchetti, A., 2003, International Society of Hypertension (ISH): Statement on Blood Pressure Lowering and Stroke Prevention. Journal of Hypertension 21, 651-663.

30. Chin, J. and Müllbacher, A., 2003, Immune activation versus hyporesponsiveness and tolerance in the gut. Gut Flora, Nutrition, Immunity and Health, eds. R.F.G. Perdigón, Blackwell: Oxford, UK. pp. 178-200.

31. Chin-Dusting, J.P.F., Ahlers, B.A., Kaye, D.M., Kelly, J.J., and Whitworth, J.A., 2003, L-arginine transport in humans with cortisol-induced hypertension. Hypertension 41(6), 1336-1340.

32. Chistiakov, D.A. and Turakulov, R.I., 2003, CTLA-4 and its role in autoimmune thyroid disease. Journal of Molecular Endocrinology 31(1), 21-36.

33. Clark, I.A. and Cowden, W.B., 2003, The pathophysiology of falciparum malaria. Pharmacology & Therapeutics 99(2), 221-260.

34. Clements, J.D., 2003, Variance-mean analysis: a simple and reliable approach for investigating synaptic transmission and modulation. Journal of Neuroscience Methods 130(2), 115-125.

35. Cousin, M.A., Malladi, C.S., Tan, T.C., Raymond, C.R., Smillie, K.J., and Robinson, P.J., 2003, Synapsin I-associated phosphatidylinositol 3-kinase mediates synaptic vesicle delivery to the readily releasable pool. Journal of Biological Chemistry 278(31), 29065-29071.

36. Cousins, H.M., Edwards, F.R., Hickey, H., Hill, C.E., and Hirst, G.D.S., 2003, Electrical coupling between the myenteric interstitial cells of Cajal and adjacent muscle layers in the guinea-pig gastric antrum. Journal of Physiology (Lond.) 550(3), 829-844.

37. Cummins, P.L. and Gready, J.E., 2003, Computational methods for the study of enzymic reaction mechanisms. II. An overlapping mechanically embedded method for hybrid semi-empirical-QM/MM calculations. Journal of Molecular Structure-Theochem 632, 247-257.

38. De Armentia, M.L., Leeson, A.H., Stebbing, M.J., Urban, L., and McLachlan, E.M., 2003, Responses to sympathomimetics in rat sensory neurones after nerve transection. Neuroreport 14, 9-14.

39. De Armentia, M.L. and Sah, P., 2003, Development and subunit composition of synaptic NMDA receptors in the amygdala: NR2B Synapses in the adult central amygdala. Journal of Neuroscience 23(17), 6876-6883.

40. de Mestre, A.M., Khachigian, L.M., Santiago, F.S., Staykova, M.A., and Hulett, M.D., 2003, Regulation of inducible heparanase gene transcription in activated T cells by early growth response 1. Journal of Biological Chemistry 278(50), 50377-50385.

41. Deeb, S.S., Wakefield, M.J., Tada, T., Marotte, L., Yokoyama, S., and Graves, J.A.M., 2003, The cone visual pigments of an Australian marsupial, the tammar wallaby (Macropus eugenii): sequence, spectral tuning and evolution. Mol Biol Evol 20(10), 1642-1649.

42. Dogra, S.C., Tremethick, D., and May, B.K., 2003, Evidence that the coactivator CBP/p300 is important for phenobarbital-induced but not basal expression of the CYP2H1 gene. Molecular Pharmacology 63(1), 73-80.

43. Dora, K.A., Sandow, S.L., Gallagher, N.T., Takano, H., Rummery, N.M., Hill, C.E., and Garland, C.H.C., 2003, Myoendothelial gap junctions may provide the pathway for EDHF in mouse mesenteric artery. Journal of Vascular Research 40(5), 480-490.

44. Drago, J., McColl, C.D., Horne, M.K., Finkelstein, D.I., and Ross, S.A., 2003, Neuronal nicotinic receptors: insights gained from gene knockout and knockin mutant mice. Review. Cell Mol Life Sci 60(7), 1267-1280.

45. Dulhunty, A.F. and Pouliquin, P., 2003, What we don't know about the structure of ryanodine receptor calcium release channels. Clinical and Experimental Pharmacology and Physiology 30(10), 713-723.

46. Duraiswamy, J., Sherritt, M., Thomson, S., Tellam, J., Cooper, L., Connolly, G., Bharadwaj, M., and Khanna, R., 2003, Therapeutic LMP1 polyepitope vaccine for EBV-associated Hodgkin disease and nasopharyngeal carcinoma. Blood 101(8), 3150-3156.

47. Eghbali, M., Birnir, B., and Gage, P.W., 2003, Conductance of GABA(A) channels activated by pentobarbitone in hippocampal neurons from newborn rats. Journal of Physiology (Lond.) 552(1), 13-22.

48. Eghbali, M., Gage, P.W., and Birnir, B., 2003, Effects of propofol on GABA(A) channel conductance in rat-cultured hippocampal neurons. European Journal of Pharmacology 468(2), 75-82.

49. Faber, E.S.L. and Sah, P., 2003, Ca2⁺-activated K⁺(BK) channel inactivation contributes to spike broadening during repetitive firing in the rat lateral amygdala. Journal of Physiology (Lond.) 552(2), 483-497.

50. Faber, E.S.L. and Sah, P., 2003, Calcium-activated potassium channels: Multiple contributions to neuronal function. Neuroscientist 9(3), 181-194.

51. Fenner, F., 2003, Smallpox. Microbiology Australia 24, 22-23.

52. Fenner, F., 2003, Erradicacion de la viruela: lecciones para el futuro (The eradication of smallpox: lessons for the future). 2nd ed. Vacunaciones Preventivas. Principios y aplicaciones., eds. L. Salleras, Barcelona: Masson. pp. 977-982.

53. Fineberg, K., Fineberg, T., Graessmann, A., Luedtke, N.W., Tor, Y., Rui, L.X., Jans, D.A., and Loyter, A., 2003, Inhibition of nuclear import mediated by the Rev-arginine rich motif by RNA molecules. Biochemistry 42(9), 2625-2633.

54. Fontes, M.R.M., Teh, T., Jans, D., Brinkworth, R.I., and Kobe, B., 2003, Structural basis for the specificity of bipartite nuclear localization sequence binding by importin-alpha. Journal of Biological Chemistry 278(30), 27981-27987.

55. Fontes, M.R.M., Teh, T., Toth, G., John, A., Pavo, I., Jans, D.A., and Kobe, B., 2003, Role of flanking sequences and phosphorylation in the recognition of the simian-virus-40 large T-antigen nuclear localization sequences by importin-alpha. Biochemical Journal 375, 339-349.

56. Foster, P.S., Webb, D.C., Yang, M., Herbert, C., and Kumar, R.K., 2003, Dissociation of T helper type 2 cytokine-dependent airway lesions from signal transducer and activator of transcription 6 signalling in experimental chronic asthma. Clinical and Experimental Allergy 33(5), 688-695.

57. Francis, D.J., Parish, C.R., McGarry, M., Santiago, F.S., Lowe, H.C., Brown, K.J., Bingley, J.A., Hayward, I.P., Cowden, W.B., Campbell, J.H., Campbell, G.R., Chesterman, C.N., and Khachigian, L.M., 2003, Blockade of vascular smooth muscle cell proliferation and intimal thickening after balloon injury by the sulfated oligosaccharide PI-88 - Phosphomannopentaose sulfate directly binds FGF-2, blocks cellular signaling, and inhibits proliferation. Circulation Research 92(8), E70-E77.

58. Fuentes, P., Cooper, P.D., Barnadas, R., Sabes, M., Osterhoff, C., and Martinez, P., 2003, Use of gamma-inulin/liposomes/Vitamin E adjuvant combination in contraceptive vaccines. International Journal of Pharmaceutics 257(1-2), 85-95.

59. Gatenby, P.A. and Whitworth, J.A., 2003, Canberra's new medical school. Internal Medicine Journal 33(7), 321-322.

60. Gebauer, M.G., McKinlay, C., and Gready, J.E., 2003, Synthesis of quaternised 2-aminopyrimido 4,5-d pyrimidin-4(3H)-ones and their biological activity with dihydrofolate reductase. European Journal of Medicinal Chemistry 38(7-8), 719-728.

61. Goodridge, J.P., Witt, C.S., Christiansen, F.T., and Warren, H.S., 2003, KIR2DL4 (CD158d) genotype influences expression and function in NK cells. Journal of Immunology 171(4), 1768-1774.

62. Gousseva, N. and Baker, R.T., 2003, Gene structure, alternate splicing, tissue distribution, cellular localization, and developmental expression pattern of mouse deubiquitinating enzyme isoforms Usp2-45 and Usp2-69. Gene Expression 11(3-4), 163-179.

63. Graham, B.A., Schofield, P.R., Sah, P., and Callister, R.J., 2003, Altered inhibitory synaptic transmission in superficial dorsal horn neurones in spastic and oscillator mice. Journal of Physiology (Lond.) 551(3), 905-916.

64. Green, D., Pace, S., Curtis, S.M., Sakowska, M., Lamb, G.D., Dulhunty, A.F., and Casarotto, M.G., 2003, The three-dimensional structural surface of two beta-sheet scorpion toxins mimics that of an alpha-helical dihydropyridine receptor segment. Biochemical Journal 370, 517-527.

65. Gulledge, A.T. and Stuart, G.J., 2003, Action potential initiation and propagation in layer 5 pyramidal neurons of the rat prefrontal cortex: absence of dopamine modulation. Journal of Neuroscience 23(36), 11363-11372.

66. Gulledge, A.T. and Stuart, G.J., 2003, Excitatory actions of GABA in the cortex. Neuron 37(2), 299-309.

67. Haarmann, C.S., Green, D., Casarotto, M.G., Laver, D.R., and Dulhunty, A.F., 2003, The random-coil 'C' fragment of the dihydropyridine receptor II-III loop can activate or inhibit native skeletal ryanodine receptors. Biochemical Journal 372, 305-316.

68. Hamer, R.D., Nicholas, S.C., Tranchina, D., Liebman, P.A., and Lamb, T.D., 2003, Multiple steps of phosphorylation of activated rhodopsin can account for the reproducibility of vertebrate rod single-photon responses. Journal of General Physiology 122(4), 419-444.

69. Hamilton-Williams, E.E., Palmer, S.E., Charlton, B., and Slattery, R.M., 2003, Beta cell MHC class I is a late requirement for diabetes. Proceedings of the National Academy of Sciences of the United States of America 100(11), 6688-6693.

70. Harley, V.R., Layfield, S., Mitchell, C.L., Forwood, J.K., John, A.P., Briggs, L.J., McDowall, S.G., and Jans, D.A., 2003, Defective importin beta recognition and nuclear import of the sex-determining factor SRY are associated with XY sex-reversing mutations. Proceedings of the National Academy of Sciences of the United States of America 100(12), 7045-7050.

71. Hirst, C.E., Buzza, M.S., Bird, C.H., Warren, H.S., Cameron, P.U., Zhang, M.L., Ashton-Rickardt, P.G., and Bird, P.I., 2003, The intracellular granzyme B inhibitor, proteinase inhibitor 9, is up-regulated during accessory cell maturation and effector cell degranulation, and its overexpression enhances CTL potency. Journal of Immunology 170(2), 805-815.

72. Holloway, A.F., Rao, S., Chen, X.X., and Shannon, M.F., 2003, Changes in chromatin accessibility across the GM-CSF promoter upon T cell activation are dependent on nuclear factor kappa B proteins. Journal of Experimental Medicine 197(4), 413-423.

73. Hoyne, G.F., 2003, Notch signaling in the immune system. Journal of Leukocyte Biology 74(6), 971-981.

74. Isaev, A., 2003, Rotationally invariant complex manifolds. J. Korean Math. Soc. 40, 391-408.

75. Jackson, M.B. and Redman, S.J., 2003, Calcium dynamics, buffering, and buffer saturation in the boutons of dentate granule-cell axons in the hilus. Journal of Neuroscience 23(5), 1612-1621.

76. Jenne, C.N., Kennedy, L.J., McCullagh, P., and Reynolds, J.D., 2003, A new model of sheep Ig diversification: Shifting the emphasis toward combinatorial mechanisms and away from hypermutation. Journal of Immunology 170(7), 3739-3750.

77. Jorm, A.F., Prior, M., Sanson, A., Smart, D., Zhang, Y.F., and Easteal, S., 2003, Apolipoprotein E genotype and temperament: A longitudinal study from infancy to the late teens. Psychosomatic Medicine 65(4), 662-664.

78. Jun, J.E. and Goodnow, C.C., 2003, Scaffolding of antigen receptors for immunogenic versus tolerogenic signaling. Nature Immunology 4(11), 1057-1064.

79. Jun, J.E., Wilson, L.E., Vinuesa, C.G., Lesage, S., Blery, M., Miosge, L.A., Cook, M.C., Kucharska, E.M., Hara, H., Penninger, J.M., Domaschenz, H., Hong, N.A., Glynne, R.J., Nelms, K.A., and Goodnow, C.C., 2003, Identifying the MAGUK protein CARMA-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis. Immunity 18(6), 751-762.

80. Kaplan, N., Mandis, S., Poulter, N., Whitworth, JA, 2003, World Health Organization (WHO)/International Society of Hypertension (ISH) statement on management of hypertension. J Hypertens 21, 1983-1992.

81. Kruse, S., Kuehr, J., Moseler, M., Kopp, M.V., Kurz, T., Deichmann, K.A., Foster, P.S., and Mattes, J., 2003, Polymorphisms in the IL18 gene are associated with specific sensitization to common allergens and allergic rhinitis. Journal of Allergy and Clinical Immunology 111(1), 117-122.

82. Kumar, R.K., Herbert, C., Thomas, P.S., Wollin, L., Beume, R., Yang, M., Webb, D.C., and Foster, P.S., 2003, Inhibition of inflammation and remodeling by roflumilast and dexamethasone in murine chronic asthma. Journal of Pharmacology and Experimental Therapeutics 307(1), 349-355.

83. Lamb, T.D. and Burns, M.E., 2003, Visual Transduction by rod and cone photoreceptors. The Visual Neurosciences, eds. L.M. Chalupa and J.S. Werner, London: MIT Press.

84. Lim, M.S.F., Lindquist, C.E.L., and Birnir, B., 2003, Effects of pentobarbital on GABA-activated currents in acutely-isolated rat dentate gyrus granule neurons. Neuroscience Letters 353(2), 139-142.

85. Lim, R., Oleskevich, S., Few, A.P., Leao, R.N., and Walmsley, B., 2003, Glycinergic mIPSCs in mouse and rat brainstem auditory nuclei: modulation by ruthenium red and the role of calcium stores. Journal of Physiology (Lond.) 546(3), 691-699.

86. Lin, R.C.Y., Schyvens, C.G., Zhang, Y., Whitworth, J.A., and Morris, B.J., 2003, Tumor necrosis factor receptor 2 mRNA in rat models of hypertension. American Journal of Hypertension 16(8), 685-688.

87. Liston, A., Lesage, S., Wilson, J., Peltonen, L., and Goodnow, C.C., 2003, Aire regulates negative selection of organ-specific T cells. Nature Immunology 4(4), 350-354.

88. Liston, A. and McColl, S.R., 2003, Subversion of the chemokine world by microbial pathogens. BioEssays 25, 478.

89. Lobigs, M., Müllbacher, A., and Lee, E., 2003, Evidence that a mechanism for efficient flavivirus budding upregulates MHC class 1. Immunology and Cell Biology 82, 184-188.

90. Lobigs, M., Mullbacher, A., and Regner, M., 2003, MHC class I up-regulation by flaviviruses: Immune interaction with unknown advantage to host or pathogen. Immunology and Cell Biology 81(3), 217-223.

91. Lobigs, M., Mullbacher, A., Wang, Y., Pavy, M., and Lee, E., 2003, Role of type I and type II interferon responses in recovery from infection with an encephalitic flavivirus. Journal of General Virology 84, 567-572.

92. Lobigs, M., Pavy, M., and Hall, R., 2003, Cross-protective and infection-enhancing immunity in mice vaccinated against flaviviruses belonging to the Japanese encephalitis virus serocomplex. Vaccine 21(15), 1572-1579.

93. Maindonald, J.H., Pittelkow, Y.E., and Wilson, S.R., 2003, Some considerations for the design of microarray experiments. Science and Statistics: A Festschrift for Terry Speed, eds. R.D. Goldstein. 40: Institute of Mathematical Statistics, Lecture Notes - Monograph series. pp. 367-390.

94. Mangos, G.J., Whitworth, J.A., Williamson, P.M., and Kelly, J.J., 2003, Glucocorticoids and the kidney. Nephrology 8(6), 267-273.

95. Masoumi, A., Hanzlik, T.N., and Christian, P.D., 2003, Functionality of the 5 '- and intergenic IRES elements of cricket paralysis virus in a range of insect cell lines, and its relationship with viral activities. Virus Research 94(2), 113-120.

96. Mattes, J. and Foster, P.S., 2003, Regulation of Eosinophil Migration and Th2 Cell Function by IL-5 and Eotaxin. Current Drug Targets - Inflammation and Allergy 2, 167-174.

97. Mattes, J., Hulett, M., Xie, W., Hogan, S., Rothenberg, M.E., Foster, P., and Parish, C., 2003, Immunotherapy of cytotoxic T cell-resistant tumors by T helper 2 cells: An eotaxin and STAT6-dependent process. Journal of Experimental Medicine 197(3), 387-393.

98. McColl, B.K., Baldwin, M.E., Roufail, S., Freeman, C., Moritz, R.L., Simpson, R.J., Alitalo, K., Stacker, S.A., and Achen, M.G., 2003, Plasmin activates the lymphangiogenic growth factors VEGF-C and VEGF-D. Journal of Experimental Medicine 198(6), 863-868.

99. McColl, C.D., Wong, J.Y.F., Finkelstein, D.I., Horne, M.K., Berkovic, S.F., and Drago, J., 2003, Electroencephalographic characterisation of mice with targeted deletion of the alpha4 nicotinic acetylcholine receptor. Neuropharmacology 44(2), 234-243.

100. McKenzie, H.A. and Frier, R.D., 2003, The behavior of R-ovalbumin and its individual components A(1), A(2), and A(3) in urea solution: Kinetics and equilibria. Journal of Protein Chemistry 22(3), 207-214.

101. McKenzie, H.A. and Frier, R.D., 2003, Behavior of S-1- and S-2-ovalbumin and S-ovalbumin A(1) in urea solution: Kinetics and equilibria. Journal of Protein Chemistry 22(3), 215-220.

102. Moerman, K.L., Chai, C.L.L., and Waring, P., 2003, Evidence that the lichen-derived scabrosin esters target mitochondrial ATP synthase in P388D1 cells. Toxicology and Applied Pharmacology 190(3), 232-240.

103. Mukherjee, S., Upham, J.W., Ramshaw, I., Bundell, C., van Bruggen, I., Robinson, B.W.S., and Nelson, D.J., 2003, Dendritic cells infected with a vaccinia virus interleukin-2 vector secrete high levels of IL-2 and can become efficient antigen presenting cells that secrete high levels of the immunostimulatory cytokine IL-12. Cancer Gene Therapy 10(8), 591-602.

104. Müllbacher, A., 2003, Cell-mediated cytotoxicity in recovery from poxvirus infections. Reviews in Medical Virology 13, 223-232.

105. Müllbacher, A., Lobigs, M., and Lee, E., 2003, Immunobiology of mosquito-borne encephalitic flaviviruses. Advances in Virus Research. 60. pp. 87-120.

106. Müller, U., Sobek, V., Balkow, S., Holscher, C., Mullbacher, A., Museteanu, C., Mossmann, H., and Simon, M.M., 2003, Concerted action of perforin and granzymes is critical for the elimination of Trypanosoma cruzi from mouse tissues, but prevention of early host death is in addition dependent on the FasL/Fas pathway. European Journal of Immunology 33(1), 70-78.

107. Murphy, J.M., Ford, S.C., Wiedemann, U.A., Carr, P.D., Ollis, D.L., and Young, I.G., 2003, A novel functional epitope formed by domains 1 and 4 of the human common beta-subunit is involved in receptor activation by granulocyte macrophage colony-stimulating factor and interleukin 5. Journal of Biological Chemistry 278(12), 10572-10577.

108. Nagashima, T., Silva, D.G., Petrovsky, N., Socha, L.A., Suzuki, H., Saito, R., Kasukawa, T., Kurochkin, I.V., Konagaya, A., and Schonbach, C., 2003, Inferring higher functional information for RIKEN mouse full-length cDNA clones with FACTS. Genome Research 13(6B), 1520-1533.

109. O'Callaghan, N.J., Adams, K.E., van Heel, D.A., and Cavanaugh, J.A., 2003, Association of TNF-alpha-857C with inflammatory bowel disease in the Australian population. Scandinavian Journal of Gastroenterology 38(5), 533-534.

110. Ozsarac, N., Weible, M., Reynolds, A.J., and Hendry, I.A., 2003, Activation of protein kinase C inhibits retrograde transport of neurotrophins in mice. Journal of Neuroscience Research 72(2), 203-210.

111. Paalangara, R., McClure, S., and McCullagh, P., 2003, Intestinal exposure to a parasite antigen in utero depresses cellular and cytokine responses of the mucosal immune system. Veterinary Immunology and Immunopathology 93(3-4), 91-105.

112. Papathanasiou, P., Perkins, A.C., Cobb, B.S., Ferrini, R., Sridharan, R., Hoyne, G.F., Nelms, K.A., Smale, S.T., and Goodnow, C.C., 2003, Widespread failure of hematolymphoid differentiation caused by a recessive niche-filling allele of the Ikaros transcription factor. Immunity 19(1), 131-144.

113. Parish, C.R., 2003, Cancer immunotherapy: The past, the present and the future. Immunology and Cell Biology 81(2), 106-113.

114. Petrovsky, N., Schonbach, C., and Brusic, V., 2003, Bioinformatic strategies for better understanding of immune function. Silico Biol. 3, 0034.

115. Petrovsky, N., Silva, D., and Brusic, V., 2003, The Future for Computational Modelling and Prediction Systems in Clinical Immunology. Immunoinformatics: Bioinformatic Strategies for Better Understanding of Immune Function. 254: Novartis Found Symp. pp. 23-32; discussion 33-42, 98-101, 250-252.

116. Petrovsky, N., Silva, D., and Schatz, D., 2003, Vaccine therapies for the prevention of type 1 (insulin-dependent) diabetes. Paediatr Drugs 5(9), 575-582.

117. Petrovsky, N., Socha, L., Silva, D., Grossman, A.B., Metz, C., and Bucala, R., 2003, Macrophage migration inhibitory factor exhibits a pronounced circadian rhythm relevant to its role as a glucocorticoid counter-regulator. Immunology and Cell Biology 81(2), 137-143.

118. Pittelkow, Y.E. and Wilson, S.R., 2003, Visualisation of Gene Expression Data: The GE-biplot, the Chip-plot and the Gene-plot. Statistical Applications in Genetics and Molecular Biology 2(1), 19.

119. Pittelkow, Y.E. and Wilson, S.R., 2003, The GE-biplot for microarray data. Virtual Conference on Genomics and Bioinformatics. Vol. 2. pp. 8-11.

120. Premzl, M., Sangiorgio, L., Strumbo, B., Graves, J.A.M., Simonic, T., and Gready, J.E., 2003, Shadoo, a new protein highly conserved from fish to mammals and with similarity to prion protein. Gene 314, 89-102.

121. Rangasamy, D., Berven, L., Ridgway, P., and Tremethick, D.J., 2003, Pericentric heterochromatin becomes enriched with H2A.Z during early mammalian development. Embo Journal 22(7), 1599-1607.

122. Rao, S., Gerondakis, S., Woltring, D., and Shannon, M.F., 2003, c-Rel is required for chromatin remodeling across the IL-2 gene promoter. Journal of Immunology 170(7), 3724-3731.

123. Raymond, C.R., Ireland, D.R., and Abraham, W.C., 2003, NMDA receptor regulation by amyloid-beta does not account for its inhibition of LTP in rat hippocampus. Brain Research 968(2), 263-272.

124. Redman, S.J. and Faber, D.S., 2003, Adapting quantal analysis to central synapses. Journal of Neuroscience Methods 130(2), 103-205.

125. Reid, C.A., Bekkers, J.M., and Clements, J.D., 2003, Presynaptic Ca2⁺ channels: a functional patchwork. Trends in Neurosciences 26(12), 683-687.

126. Rolph, M.S. and Ramshaw, I.A., 2003, Interleukin-4-mediated downregulation of cytotoxic T lymphocyte activity is associated with reduced proliferation of antigen-specific CD8(+) T cells. Microbes and Infection 5(11), 923-932.

127. Rosenkranz, A.A., Lunin, V.G., Gulak, P.V., Sergienko, O.V., Shumiantseva, M.A., Voronina, O.L., Gilyazova, D.G., John, A.P., Kofner, A.A., Mironov, A.F., Jans, D.A., and Sobolev, A.S., 2003, Recombinant modular transporters for cell-specific nuclear delivery of locally acting drugs enhance photosensitizer activity. Faseb Journal 17(6).

128. Rui, L.X., Vinuesa, C.G., Blasioli, J., and Goodnow, C.C., 2003, Resistance to CpG DNA-induced autoimmunity through tolerogenic B cell antigen receptor ERK signaling. Nature Immunology 4(6), 594-600.

129. Sah, P. and De Armentia, M.L., 2003, Excitatory synaptic transmission in the lateral and central amygdala. Amygdala in Brain Function: Basic and Clinical Approaches 985, 67-77.

130. Sah, P., Faber, E.S.L., De Armentia, M.L., and Power, J., 2003, The amygdaloid complex: Anatomy and physiology. Physiological Reviews 83(3), 803-834.

131. Sandow, S.L., Bramich, N.J., Bandi, H.P., Rummery, N.M., and Hill, C.E., 2003, Structure, function, and endothelium-derived hyperpolarizing factor in the caudal artery of the SHR and WKY rat. Arteriosclerosis Thrombosis and Vascular Biology 23(5), 822-828.

132. Sandow, S.L., Bramich, N.J., Bandi, H.P., Rummery, N.M., and Hill, C.E., 2003, Endothelium-derived hyperpolarizing factor, myoendothelial gap junctions and hypertension. EDHF 2002, ed. P.M. Vanhoutte: Taylor and Francis Publishers. UK. pp. 108-116.

133. Sandow, S.L., Looft-Wilson, R., Doran, B., Grayson, T.H., Segal, S.S., and Hill, C.E., 2003, Expression of homocellular and heterocellular gap junctions in hamster arterioles and feed arteries. Cardiovascular Research 60(3), 643-653.

134. Sangalli, M.R., McLean, A.J., Peek, M.J., Rivory, L.P., and Le Couteur, D.G., 2003, Carbon monoxide disposition and permeability-surface area product in the foetal circulation of the perfused term human placenta. Placenta 24(1), 8-11.

135. Schedlich, L.J., Nilsen, T., John, A.P., Jans, D.A., and Baxter, R.C., 2003, Phosphorylation of insulin-like growth factor binding protein-3 by deoxyribonucleic acid-dependent protein kinase reduces ligand binding and enhances nuclear accumulation. Endocrinology 144(5), 1984-1993.

136. Shannon, M.F., 2003, A nuclear address with influence. Nature Genetics 34(1), 4-6.

137. Silva, D.G., Charlton, B., Cowden, W., and Petrovsky, N., 2003, Prevention of autoimmune diabetes through immunostimulation with Q fever complement-fixing antigen. Immunology of Diabetes II: Pathogenesis from Mouse to Man 1005, 423-430.

138. Silva, D.G., Petrovsky, N., Socha, L., Slattery, R., Gatenby, P., and Charlton, B., 2003, Mechanisms of accelerated immune-mediated diabetes resulting from islet beta cell expression of a Fas ligand transgene. Journal of Immunology 170(10), 4996-5002.

139. Silva, D.G., Schonbach, C., Brusic, V., Socha, L.A., Nagashima, T., and Petrovsky, N., 2003, Identification of novel "pathologs" (human disease-related gene candidates) from the RIKEN full-length mouse cDNA data set. Genome Research 13(6B), 1559.

140. Silva, D.G., Socha, L., Charlton, B., Cowden, W., and Petrovsky, N., 2003, Autoimmune diabetes in the NOD mouse: An essential role of Fas-FasL signaling in beta cell apoptosis. Immunology of Diabetes II: Pathogenesis from Mouse to Man 1005, 161-165.

141. Smart, V., Foster, P.S., Rothenberg, M.E., Higgins, T.J.V., and Hogan, S.P., 2003, A plant-based allergy vaccine suppresses experimental asthma via an IFN-gamma and CD4(+) CD45RB(low) T cell-dependent mechanism. Journal of Immunology 171(4), 2116-2126.

142. Socha, L., Silva, D., Lesage, S., Goodnow, C., and Petrovsky, N., 2003, The role of endoplasmic reticulum stress in nonimmune diabetes: NOD.K iHEL, a novel model of beta cell death. Immunology of Diabetes II: Pathogenesis from Mouse to Man 1005, 178-183.

143. Solomon, M.F., Kuziel, W.A., Mann, D.A., and Simeonovic, C.J., 2003, The role of chemokines and their receptors in the rejection of pig islet tissue xenografts. Xenotransplantation 10(2), 164-177.

144. Spinner, E., 2003, Raman-spectral depolarisation ratios of ions in concentrated aqueous solution. The next-to-negligible effect of highly asymmetric ion surroundings on the symmetry properties of polarisability changes during vibrations of symmetric ions. Ammonium sulphate and tetramethylammonium bromide. Spectrochimica Acta Part a-Molecular and Biomolecular Spectroscopy 59(7), 1441-1456.

145. Spinner, E., 2003, Effects of modification of molecular structure on Raman spectral depolarization ratios: aqueous betaine (CH3)(3)NCH2CO2 center dot 29D(2)O versus (CH3)(4)NBr center dot 29D(2)O. Spectrochimica Acta Part a-Molecular and Biomolecular Spectroscopy 59(7), 1457-1468.

146. Staykova, M.A., Berven, L.A., Cowden, W.B., Willenborg, D.O., and Crouch, M.F., 2003, Nitric oxide induces polarization of actin in encephalitogenic T cells and inhibits their in vitro transendothelial migration in a p70S6 kinase-independent manner. Faseb Journal 17(8).

147. Stewart, G.A., Hoyne, G.F., Ahmad, S.A., Jarman, E., Wallace, W.A., Harrison, D.J., Haslett, C., Lamb, J.R., and Howie, S.E., 2003, Expression of the developmental Sonic hedgehog (Shh) signalling pathway is up-regulated in chronic lung fibrosis and the Shh receptor patched 1 is present in circulating T lymphocytes. J Pathol 199, 488-495.

148. Stoll, V., Stewart, K.D., Maring, C.J., Muchmore, S., Giranda, V., Gu, Y.G.Y., Wang, G., Chen, Y.W., Sun, M.H., Zhao, C., Kennedy, A.L., Madigan, D.L., Xu, Y.B., Saldivar, A., Kati, W., Laver, G., Sowin, T., Sham, H.L., Greer, J., and Kempf, D., 2003, Influenza neuraminidase inhibitors: Structure-based design of a novel inhibitor series. Biochemistry 42(3), 718-727.

149. Stricker, C. and Redman, S.J., 2003, Quantal analysis based on density estimation. Journal of Neuroscience Methods 130(2), 159-171.

150. Tare, M., Sandow, S.L., Coleman, H.A., Wigg, S.J., Parkington, H.C., and Hill, C.E., 2003, Myoendothelial gap junctions - the critical link for endothelium-derived hyperpolarizing factor. EDHF 2002, ed. P.M. Vanhoutte: Taylor and Francis Publishers. UK.

151. Turakulov, R. and Easteal, S., 2003, Number of SNPS loci needed to detect population structure. Human Heredity 55(1), 37-45.

152. Vinuesa, C.G., Sze, D.M.-Y., Cook, M.C., Toellner, K.-M., Klaus, G.G.B., Ball, J., and MacLennan, I.C.M., 2003, Recirculating and germinal center B cells differentiate into cells responsive to polysaccharide antigens. Eur J Immunol 33, 297-305.

153. Volkmann, L., Bain, O., Saeftel, M., Specht, S., Fischer, K., Brombacher, F., Matthaei, K.I., and Hoerauf, A., 2003, Murine filariasis: interleukin 4 and interleukin 5 lead to containment of different worm developmental stages. Medical Microbiology and Immunology 192(1), 23-31.

154. Wakefield, M.J. and Graves, J.A.M., 2003, The Kangaroo Genome: Leaps and bounds in comparative genomics. EMBO Reports 4, 143-147.

155. Wakefield, M.J. and Graves, J.A.M., 2003, Kangaroo Genomics Leaps Ahead. Today's Life Science 15(3), 34-37.

156. Wang, Y., Lobigs, M., Lee, E., and Mullbacher, A., 2003, CD8(+) T cells mediate recovery and immunopathology in west nile virus encephalitis. Journal of Virology 77(24), 13323-13334.

157. Warren, H.S., Christiansen, F.T., and Witt, C.S., 2003, Functional inhibitory human leucocyte antigen class I receptors on natural killer (NK) cells in patients with chronic NK lymphocytosis. British Journal of Haematology 121(5), 793-804.

158. Warren, H.S. and Rana, P.M., 2003, An economical adaptation of the RosetteSep (TM) procedure for NK cell enrichment from whole blood, and its use with liquid nitrogen stored peripheral blood mononuclear cells. Journal of Immunological Methods 280(1-2), 135-138.

159. Webb, D.C., Mahalingam, S., Cai, Y.P., Matthaei, K.I., Donaldson, D.D., and Foster, P.S., 2003, Antigen-specific production of interleukin (IL)-13 and IL-5 cooperate to mediate IL-4R alpha-independent airway hyperreactivity. European Journal of Immunology 33(12), 3377-3385.

160. Whitbread, A.K., Tetlow, N., Eyre, H.J., Sutherland, G.R., and Board, P.G., 2003, Characterization of the human Omega class glutathione transferase genes and associated polymorphisms. Pharmacogenetics 13(3), 131-144.

161. Whitworth, J.A., 2003, The Sylvia and Charles Viertel Charitable Foundation: A decade of support for medical research in Australia. Internal Medicine Journal 33(12), 610-612.

162. Whitworth, J.A., 2003, Hypertension: a major global health problem. Kidney 12, 103-104.

163. Whitworth, J.A., 2003, Emerging drugs in the management of hypertension. Expert Opin Emerg Drugs 8, 377-388.

164. Williams, S.R. and Stuart, G.J., 2003, Voltage- and site-dependent control of the somatic impact of dendritic IPSPs. Journal of Neuroscience 23(19), 7358-7367.

165. Williams, S.R. and Stuart, G.J., 2003, Role of dendritic synapse location in the control of action potential output. Trends in Neurosciences 26(3), 147-154.

166. Willoughby, J., Fitzgibbon, S., Pope, K., Mackenzie, L., Medvedev, A., Clark, C., Davey, M., and Wilcox, R., 2003, Persistent abnormality detected in the non-ictal electroencephalogram in primary generalised epilepsy. Journal of Neurology, Neurosurgery and Psychiatry 74(1), 51-55.

167. Wilson, S.R., 2003, Invited discussion of 'Ancestral inference in population genetics models with selection' by M Stephens & P Donnelly. Australian & New Zealand Journal of Statistics 45, 423-426.

168. Wing, L.M.H., Reid, C.M., Ryan, P., Beilin, L.J., Brown, M.A., Jennings, G.L.R., Johnston, C.I., McNeil, J.J., MacDonald, G.J., Marley, J.E., Morgan, T.O., West, M.J., and Whitworth, J.A., 2003, For the Second Australian National Blood Pressure Study Group. A comparison of outcomes with angiotensin-converting-enzyme inhibitors and diuretics for the treatment of hypertension in the elderly. The New England Journal of Medicine 348(7), 583-592.

169. Yang, M., Hogan, S.P., Mahalingam, S., Pope, S.M., Zimmermann, N., Fulkerson, P., Dent, L.A., Young, I.G., Matthaei, K.I., Rothenberg, M.E., and Foster, P.S., 2003, Eotaxin-2 and IL5 cooperate in the lung to regulate IL-13 production and airway eosinophilia and hyperreactivity. Journal of Allergy and Clinical Immunology 112(5), 935-943.

170. Yang, N., MacArthur, D.G., Gulbin, J.P., Hahn, A.G., Beggs, A.H., Easteal, S., and North, K., 2003, ACTN3 genotype is associated with human elite athletic performance. American Journal of Human Genetics 73(3), 627-631.

171. Zelensky, A.N. and Gready, J.E., 2003, Comparative analysis of structural properties of the C-type-lectin-like domain (CTLD). Proteins-Structure Function and Genetics 52(3), 466-477.

172. Zhang, M.F., Vacchio, M.S., Vistica, B.P., Lesage, S., Egwuagu, C.E., Yu, C.R., Gelderman, M.P., Kennedy, M.C., Wawrousek, E.F., and Gery, I., 2003, T cell tolerance to a neo-self antigen expressed by thymic epithelial cells: The soluble form is more effective than the membrane-bound form. Journal of Immunology 170(8), 3954-3962.

173. Zhang, Y., Jang, R., Mori, T.A., Croft, K.D., Schyvens, C.G., McKenzie, K.U.S., and Whitworth, J.A., 2003, The anti-oxidant Tempol reverses and partially prevents adrenocorticotrophic hormone-induced hypertension in the rat. Journal of Hypertension 21(8), 1513-1518.

174. Zhang, Y., Schyvens, C.G., McKenzie, K.U.S., Morris, B.J., and Whitworth, J.A., 2003, Lipopolysaccharide reverses adrenocorticotrophic hormone-induced hypertension in the rat. Hypertension Research 26(5), 427-432.

175. Zimmermann, N., Hershey, G.K., Foster, P.S., and Rothenberg, M.E., 2003, Chemokines in asthma: Cooperative interaction between chemokines and IL-13. Journal of Allergy and Clinical Immunology 111(2), 227-242.

176. Zimmermann, N., King, N.E., Laporte, J., Yang, M., Mishra, A., Pope, S.M., Muntel, E.E., Witte, D.P., Pegg, A.A., Foster, P.S., Hamid, Q., and Rothenberg, M.E., 2003, Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis. Journal of Clinical Investigation 111(12), 1863-1874.

177. Zuegg, J., Bliznyuk, A.A., and Gready, J.E., 2003, Comparison of electrostatic potential around proteins calculated from Amber and AM1 charges: application to mutants of prion protein. Molecular Physics 101(15), 2437-2450.

178. Zylstra, P., Franklin, A., Hassan, K.A., Powell, K.L., Steele, E.J., and Blanden, R.V., 2003, Molecular evolution of V(H)9 germline genes isolated from DBA, BALB, 129 and C57BL mouse strains and sublines. Immunogenetics 55(3), 182-188.